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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles p...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324276/ https://www.ncbi.nlm.nih.gov/pubmed/28231783 http://dx.doi.org/10.1186/s12916-017-0778-8 |
| _version_ | 1782510193460903936 |
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| author | Di Donato, Ilaria Bianchi, Silvia De Stefano, Nicola Dichgans, Martin Dotti, Maria Teresa Duering, Marco Jouvent, Eric Korczyn, Amos D. Lesnik-Oberstein, Saskia A. J. Malandrini, Alessandro Markus, Hugh S. Pantoni, Leonardo Penco, Silvana Rufa, Alessandra Sinanović, Osman Stojanov, Dragan Federico, Antonio |
| author_facet | Di Donato, Ilaria Bianchi, Silvia De Stefano, Nicola Dichgans, Martin Dotti, Maria Teresa Duering, Marco Jouvent, Eric Korczyn, Amos D. Lesnik-Oberstein, Saskia A. J. Malandrini, Alessandro Markus, Hugh S. Pantoni, Leonardo Penco, Silvana Rufa, Alessandra Sinanović, Osman Stojanov, Dragan Federico, Antonio |
| author_sort | Di Donato, Ilaria |
| collection | PubMed |
| description | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients. |
| format | Online Article Text |
| id | pubmed-5324276 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53242762017-03-01 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects Di Donato, Ilaria Bianchi, Silvia De Stefano, Nicola Dichgans, Martin Dotti, Maria Teresa Duering, Marco Jouvent, Eric Korczyn, Amos D. Lesnik-Oberstein, Saskia A. J. Malandrini, Alessandro Markus, Hugh S. Pantoni, Leonardo Penco, Silvana Rufa, Alessandra Sinanović, Osman Stojanov, Dragan Federico, Antonio BMC Med Review Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients. BioMed Central 2017-02-24 /pmc/articles/PMC5324276/ /pubmed/28231783 http://dx.doi.org/10.1186/s12916-017-0778-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Di Donato, Ilaria Bianchi, Silvia De Stefano, Nicola Dichgans, Martin Dotti, Maria Teresa Duering, Marco Jouvent, Eric Korczyn, Amos D. Lesnik-Oberstein, Saskia A. J. Malandrini, Alessandro Markus, Hugh S. Pantoni, Leonardo Penco, Silvana Rufa, Alessandra Sinanović, Osman Stojanov, Dragan Federico, Antonio Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| title | Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| title_full | Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| title_fullStr | Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| title_full_unstemmed | Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| title_short | Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| title_sort | cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil) as a model of small vessel disease: update on clinical, diagnostic, and management aspects |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324276/ https://www.ncbi.nlm.nih.gov/pubmed/28231783 http://dx.doi.org/10.1186/s12916-017-0778-8 |
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