SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation

BACKGROUND: Epigenetic regulation of chromatin states is thought to control the self-renewal and differentiation of embryonic stem (ES) cells. However, the roles of repressive histone modifications such as trimethylated histone 4 lysine 20 (H4K20me3) in pluripotency and development are largely unkno...

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Detalles Bibliográficos
Autores principales: Kidder, Benjamin L., Hu, Gangqing, Cui, Kairong, Zhao, Keji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324308/
https://www.ncbi.nlm.nih.gov/pubmed/28250819
http://dx.doi.org/10.1186/s13072-017-0115-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324308/
https://www.ncbi.nlm.nih.gov/pubmed/28250819
http://dx.doi.org/10.1186/s13072-017-0115-7

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