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Tonotopic maps in human auditory cortex using arterial spin labeling

A tonotopic organization of the human auditory cortex (AC) has been reliably found by neuroimaging studies. However, a full characterization and parcellation of the AC is still lacking. In this study, we employed pseudo‐continuous arterial spin labeling (pCASL) to map tonotopy and voice selective re...

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Autores principales: Gardumi, Anna, Ivanov, Dimo, Havlicek, Martin, Formisano, Elia, Uludağ, Kâmil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324648/
https://www.ncbi.nlm.nih.gov/pubmed/27790786
http://dx.doi.org/10.1002/hbm.23444
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author Gardumi, Anna
Ivanov, Dimo
Havlicek, Martin
Formisano, Elia
Uludağ, Kâmil
author_facet Gardumi, Anna
Ivanov, Dimo
Havlicek, Martin
Formisano, Elia
Uludağ, Kâmil
author_sort Gardumi, Anna
collection PubMed
description A tonotopic organization of the human auditory cortex (AC) has been reliably found by neuroimaging studies. However, a full characterization and parcellation of the AC is still lacking. In this study, we employed pseudo‐continuous arterial spin labeling (pCASL) to map tonotopy and voice selective regions using, for the first time, cerebral blood flow (CBF). We demonstrated the feasibility of CBF‐based tonotopy and found a good agreement with BOLD signal‐based tonotopy, despite the lower contrast‐to‐noise ratio of CBF. Quantitative perfusion mapping of baseline CBF showed a region of high perfusion centered on Heschl's gyrus and corresponding to the main high‐low‐high frequency gradients, co‐located to the presumed primary auditory core and suggesting baseline CBF as a novel marker for AC parcellation. Furthermore, susceptibility weighted imaging was employed to investigate the tissue specificity of CBF and BOLD signal and the possible venous bias of BOLD‐based tonotopy. For BOLD only active voxels, we found a higher percentage of vein contamination than for CBF only active voxels. Taken together, we demonstrated that both baseline and stimulus‐induced CBF is an alternative fMRI approach to the standard BOLD signal to study auditory processing and delineate the functional organization of the auditory cortex. Hum Brain Mapp 38:1140–1154, 2017. © 2016 Wiley Periodicals, Inc.
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spelling pubmed-53246482017-03-08 Tonotopic maps in human auditory cortex using arterial spin labeling Gardumi, Anna Ivanov, Dimo Havlicek, Martin Formisano, Elia Uludağ, Kâmil Hum Brain Mapp Research Articles A tonotopic organization of the human auditory cortex (AC) has been reliably found by neuroimaging studies. However, a full characterization and parcellation of the AC is still lacking. In this study, we employed pseudo‐continuous arterial spin labeling (pCASL) to map tonotopy and voice selective regions using, for the first time, cerebral blood flow (CBF). We demonstrated the feasibility of CBF‐based tonotopy and found a good agreement with BOLD signal‐based tonotopy, despite the lower contrast‐to‐noise ratio of CBF. Quantitative perfusion mapping of baseline CBF showed a region of high perfusion centered on Heschl's gyrus and corresponding to the main high‐low‐high frequency gradients, co‐located to the presumed primary auditory core and suggesting baseline CBF as a novel marker for AC parcellation. Furthermore, susceptibility weighted imaging was employed to investigate the tissue specificity of CBF and BOLD signal and the possible venous bias of BOLD‐based tonotopy. For BOLD only active voxels, we found a higher percentage of vein contamination than for CBF only active voxels. Taken together, we demonstrated that both baseline and stimulus‐induced CBF is an alternative fMRI approach to the standard BOLD signal to study auditory processing and delineate the functional organization of the auditory cortex. Hum Brain Mapp 38:1140–1154, 2017. © 2016 Wiley Periodicals, Inc. John Wiley and Sons Inc. 2016-10-28 /pmc/articles/PMC5324648/ /pubmed/27790786 http://dx.doi.org/10.1002/hbm.23444 Text en © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Gardumi, Anna
Ivanov, Dimo
Havlicek, Martin
Formisano, Elia
Uludağ, Kâmil
Tonotopic maps in human auditory cortex using arterial spin labeling
title Tonotopic maps in human auditory cortex using arterial spin labeling
title_full Tonotopic maps in human auditory cortex using arterial spin labeling
title_fullStr Tonotopic maps in human auditory cortex using arterial spin labeling
title_full_unstemmed Tonotopic maps in human auditory cortex using arterial spin labeling
title_short Tonotopic maps in human auditory cortex using arterial spin labeling
title_sort tonotopic maps in human auditory cortex using arterial spin labeling
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324648/
https://www.ncbi.nlm.nih.gov/pubmed/27790786
http://dx.doi.org/10.1002/hbm.23444
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