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Copper is a Cofactor of the Formylglycine‐Generating Enzyme

Formylglycine‐generating enzyme (FGE) is an O(2)‐utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that Cu(I) is an integral cofactor of this enzyme and binds with high affinity (K (D)=of 10(−17) m) to a pair of active‐site cysteines. These find...

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Detalles Bibliográficos
Autores principales:	Knop, Matthias, Dang, Thanh Quy, Jeschke, Gunnar, Seebeck, Florian P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324649/ https://www.ncbi.nlm.nih.gov/pubmed/27862795 http://dx.doi.org/10.1002/cbic.201600359

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