Risk Factors for Disseminated Coccidioidomycosis, United States

Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/...

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Autores principales: Odio, Camila D., Marciano, Beatriz E., Galgiani, John N., Holland, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324825/
https://www.ncbi.nlm.nih.gov/pubmed/28098554
http://dx.doi.org/10.3201/eid2302.160505
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author Odio, Camila D.
Marciano, Beatriz E.
Galgiani, John N.
Holland, Steven M.
author_facet Odio, Camila D.
Marciano, Beatriz E.
Galgiani, John N.
Holland, Steven M.
author_sort Odio, Camila D.
collection PubMed
description Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.
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spelling pubmed-53248252017-02-24 Risk Factors for Disseminated Coccidioidomycosis, United States Odio, Camila D. Marciano, Beatriz E. Galgiani, John N. Holland, Steven M. Emerg Infect Dis Dispatch Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways. Centers for Disease Control and Prevention 2017-02 /pmc/articles/PMC5324825/ /pubmed/28098554 http://dx.doi.org/10.3201/eid2302.160505 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Odio, Camila D.
Marciano, Beatriz E.
Galgiani, John N.
Holland, Steven M.
Risk Factors for Disseminated Coccidioidomycosis, United States
title Risk Factors for Disseminated Coccidioidomycosis, United States
title_full Risk Factors for Disseminated Coccidioidomycosis, United States
title_fullStr Risk Factors for Disseminated Coccidioidomycosis, United States
title_full_unstemmed Risk Factors for Disseminated Coccidioidomycosis, United States
title_short Risk Factors for Disseminated Coccidioidomycosis, United States
title_sort risk factors for disseminated coccidioidomycosis, united states
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324825/
https://www.ncbi.nlm.nih.gov/pubmed/28098554
http://dx.doi.org/10.3201/eid2302.160505
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