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An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque

OBJECTIVE: Carotid intima-media thickness (CIMT) is reliable marker of subclinical atherosclerosis and cardiovascular events. Until today, there was no study that investigated whether epicardial adipose tissue (EAT), which is a surrogate for lipid depot in a special visceral tissue or circulating li...

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Autores principales: Kocaman, Sinan Altan, Baysan, Oben, Çetin, Mustafa, Altuner, Tuğba Kayhan, Ocaklı, Ezgi Polat, Durakoğlugil, Murtaza Emre, Erdoğan, Turan, Karaoğuz, Mustafa Remzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324864/
https://www.ncbi.nlm.nih.gov/pubmed/27564776
http://dx.doi.org/10.14744/AnatolJCardiol.2016.6885
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author Kocaman, Sinan Altan
Baysan, Oben
Çetin, Mustafa
Altuner, Tuğba Kayhan
Ocaklı, Ezgi Polat
Durakoğlugil, Murtaza Emre
Erdoğan, Turan
Karaoğuz, Mustafa Remzi
author_facet Kocaman, Sinan Altan
Baysan, Oben
Çetin, Mustafa
Altuner, Tuğba Kayhan
Ocaklı, Ezgi Polat
Durakoğlugil, Murtaza Emre
Erdoğan, Turan
Karaoğuz, Mustafa Remzi
author_sort Kocaman, Sinan Altan
collection PubMed
description OBJECTIVE: Carotid intima-media thickness (CIMT) is reliable marker of subclinical atherosclerosis and cardiovascular events. Until today, there was no study that investigated whether epicardial adipose tissue (EAT), which is a surrogate for lipid depot in a special visceral tissue or circulating lipids, is more important for CIMT and atherosclerotic plaque. METHODS: Our study, having cross-sectional and prospective observational design, included 252 patients who were admitted to our outpatient clinic. EAT identified as an echo-free space under the pericardial layer on 2-dimensional echocardiography, was measured perpendicularly in front of the right ventricular free wall at end-systole. RESULTS: EAT significantly correlated with CIMT (r=0.623, p<0.001). CIMT was significantly increased with rising EAT thickness (0.72±0.15 mm, 0.85±0.16 mm, and 0.95±0.12 mm in patients with EAT <5 mm, 5–7, and >7 mm, p<0.001, respectively). Multiple linear regression analysis revealed that age (Beta: 0.406, p<0.001), male gender (Beta: 0.244, p<0.001), and EAT (Beta: 0.450, p<0.001) as independent correlates of CIMT. Otherwise, in logistic regression analysis, only EAT (OR, 1.386; 95% CI, 1.203–1.597, p<0.001) and LDL cholesterol (OR, 1.013; 95% CI, 1.002–1.013, p=0.02) were independent predictors for presence of carotid plaque. CONCLUSION: Our study showed that EAT has a relationship with both CIMT and the presence of carotid plaque, but LDL is independently related to the plaque. This finding suggests that EAT thickness may be a risk factor and biomarker, playing an important role beginning from early stages of atherosclerosis, unlike LDL cholesterol, which appear to have a role in later stages of atherosclerosis.
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spelling pubmed-53248642017-06-28 An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque Kocaman, Sinan Altan Baysan, Oben Çetin, Mustafa Altuner, Tuğba Kayhan Ocaklı, Ezgi Polat Durakoğlugil, Murtaza Emre Erdoğan, Turan Karaoğuz, Mustafa Remzi Anatol J Cardiol Original Investigation OBJECTIVE: Carotid intima-media thickness (CIMT) is reliable marker of subclinical atherosclerosis and cardiovascular events. Until today, there was no study that investigated whether epicardial adipose tissue (EAT), which is a surrogate for lipid depot in a special visceral tissue or circulating lipids, is more important for CIMT and atherosclerotic plaque. METHODS: Our study, having cross-sectional and prospective observational design, included 252 patients who were admitted to our outpatient clinic. EAT identified as an echo-free space under the pericardial layer on 2-dimensional echocardiography, was measured perpendicularly in front of the right ventricular free wall at end-systole. RESULTS: EAT significantly correlated with CIMT (r=0.623, p<0.001). CIMT was significantly increased with rising EAT thickness (0.72±0.15 mm, 0.85±0.16 mm, and 0.95±0.12 mm in patients with EAT <5 mm, 5–7, and >7 mm, p<0.001, respectively). Multiple linear regression analysis revealed that age (Beta: 0.406, p<0.001), male gender (Beta: 0.244, p<0.001), and EAT (Beta: 0.450, p<0.001) as independent correlates of CIMT. Otherwise, in logistic regression analysis, only EAT (OR, 1.386; 95% CI, 1.203–1.597, p<0.001) and LDL cholesterol (OR, 1.013; 95% CI, 1.002–1.013, p=0.02) were independent predictors for presence of carotid plaque. CONCLUSION: Our study showed that EAT has a relationship with both CIMT and the presence of carotid plaque, but LDL is independently related to the plaque. This finding suggests that EAT thickness may be a risk factor and biomarker, playing an important role beginning from early stages of atherosclerosis, unlike LDL cholesterol, which appear to have a role in later stages of atherosclerosis. Kare Publishing 2017-01 2016-08-23 /pmc/articles/PMC5324864/ /pubmed/27564776 http://dx.doi.org/10.14744/AnatolJCardiol.2016.6885 Text en Copyright © 2017 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Kocaman, Sinan Altan
Baysan, Oben
Çetin, Mustafa
Altuner, Tuğba Kayhan
Ocaklı, Ezgi Polat
Durakoğlugil, Murtaza Emre
Erdoğan, Turan
Karaoğuz, Mustafa Remzi
An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque
title An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque
title_full An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque
title_fullStr An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque
title_full_unstemmed An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque
title_short An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque
title_sort increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but ldl only with the plaque
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324864/
https://www.ncbi.nlm.nih.gov/pubmed/27564776
http://dx.doi.org/10.14744/AnatolJCardiol.2016.6885
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