Cargando…
Sarcopenia correlates with systemic inflammation in COPD
BACKGROUND: Muscle wasting and chronic inflammation are predominant features of patients with COPD. Systemic inflammation is associated with an accelerated decline in lung function. In this study, the prevalence of sarcopenia and the relationships between sarcopenia and systemic inflammations in pat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325093/ https://www.ncbi.nlm.nih.gov/pubmed/28255238 http://dx.doi.org/10.2147/COPD.S130790 |
_version_ | 1782510316037341184 |
---|---|
author | Byun, Min Kwang Cho, Eun Na Chang, Joon Ahn, Chul Min Kim, Hyung Jung |
author_facet | Byun, Min Kwang Cho, Eun Na Chang, Joon Ahn, Chul Min Kim, Hyung Jung |
author_sort | Byun, Min Kwang |
collection | PubMed |
description | BACKGROUND: Muscle wasting and chronic inflammation are predominant features of patients with COPD. Systemic inflammation is associated with an accelerated decline in lung function. In this study, the prevalence of sarcopenia and the relationships between sarcopenia and systemic inflammations in patients with stable COPD were investigated. MATERIALS AND METHODS: In a cross-sectional design, muscle strength and muscle mass were measured by handgrip strength (HGS) and bioelectrical impedance analysis in 80 patients with stable COPD. Patients (≥40 years old) diagnosed with COPD were recruited from outpatient clinics, and then COPD stages were classified. Sarcopenia was defined as the presence of both low muscle strength (by HGS) and low muscle mass (skeletal muscle mass index [SMMI]). Levels of circulating inflammatory biomarkers (IL-6 and high-sensitivity TNFα [hsTNFα]) were measured. RESULTS: Sarcopenia was prevalent in 20 (25%) patients. Patients with sarcopenia were older, had lower body mass index, and a higher percentage of cardiovascular diseases. In addition, they had significantly higher modified Medical Research Council scores and lower 6-minute walk distance than those without sarcopenia. HGS was significantly correlated with age, modified Medical Research Council score, and COPD Assessment Test scores. Both HGS and SMMI had associations with IL-6 and hsTNFα (HGS, r=−0.35, P=0.002; SMMI, r=−0.246, P=0.044) level. In multivariate analysis, old age, lower body mass index, presence of cardiovascular comorbidities, and higher hsTNFα levels were significant determinants for sarcopenia in patients with stable COPD. CONCLUSION: Sarcopenia is very common in patients with stable COPD, and is associated with more severe dyspnea-scale scores and lower exercise tolerance. Systemic inflammation could be an important contributor to sarcopenia in the stable COPD population. |
format | Online Article Text |
id | pubmed-5325093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53250932017-03-02 Sarcopenia correlates with systemic inflammation in COPD Byun, Min Kwang Cho, Eun Na Chang, Joon Ahn, Chul Min Kim, Hyung Jung Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Muscle wasting and chronic inflammation are predominant features of patients with COPD. Systemic inflammation is associated with an accelerated decline in lung function. In this study, the prevalence of sarcopenia and the relationships between sarcopenia and systemic inflammations in patients with stable COPD were investigated. MATERIALS AND METHODS: In a cross-sectional design, muscle strength and muscle mass were measured by handgrip strength (HGS) and bioelectrical impedance analysis in 80 patients with stable COPD. Patients (≥40 years old) diagnosed with COPD were recruited from outpatient clinics, and then COPD stages were classified. Sarcopenia was defined as the presence of both low muscle strength (by HGS) and low muscle mass (skeletal muscle mass index [SMMI]). Levels of circulating inflammatory biomarkers (IL-6 and high-sensitivity TNFα [hsTNFα]) were measured. RESULTS: Sarcopenia was prevalent in 20 (25%) patients. Patients with sarcopenia were older, had lower body mass index, and a higher percentage of cardiovascular diseases. In addition, they had significantly higher modified Medical Research Council scores and lower 6-minute walk distance than those without sarcopenia. HGS was significantly correlated with age, modified Medical Research Council score, and COPD Assessment Test scores. Both HGS and SMMI had associations with IL-6 and hsTNFα (HGS, r=−0.35, P=0.002; SMMI, r=−0.246, P=0.044) level. In multivariate analysis, old age, lower body mass index, presence of cardiovascular comorbidities, and higher hsTNFα levels were significant determinants for sarcopenia in patients with stable COPD. CONCLUSION: Sarcopenia is very common in patients with stable COPD, and is associated with more severe dyspnea-scale scores and lower exercise tolerance. Systemic inflammation could be an important contributor to sarcopenia in the stable COPD population. Dove Medical Press 2017-02-20 /pmc/articles/PMC5325093/ /pubmed/28255238 http://dx.doi.org/10.2147/COPD.S130790 Text en © 2017 Byun et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Byun, Min Kwang Cho, Eun Na Chang, Joon Ahn, Chul Min Kim, Hyung Jung Sarcopenia correlates with systemic inflammation in COPD |
title | Sarcopenia correlates with systemic inflammation in COPD |
title_full | Sarcopenia correlates with systemic inflammation in COPD |
title_fullStr | Sarcopenia correlates with systemic inflammation in COPD |
title_full_unstemmed | Sarcopenia correlates with systemic inflammation in COPD |
title_short | Sarcopenia correlates with systemic inflammation in COPD |
title_sort | sarcopenia correlates with systemic inflammation in copd |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325093/ https://www.ncbi.nlm.nih.gov/pubmed/28255238 http://dx.doi.org/10.2147/COPD.S130790 |
work_keys_str_mv | AT byunminkwang sarcopeniacorrelateswithsystemicinflammationincopd AT choeunna sarcopeniacorrelateswithsystemicinflammationincopd AT changjoon sarcopeniacorrelateswithsystemicinflammationincopd AT ahnchulmin sarcopeniacorrelateswithsystemicinflammationincopd AT kimhyungjung sarcopeniacorrelateswithsystemicinflammationincopd |