Chemoproteomic profiling and discovery of protein electrophiles in human cells

Activity-based protein profiling (ABPP) serves as a chemical proteomic platform to discover and characterize functional amino acids in proteins on the basis of their enhanced reactivity towards small-molecule probes. This approach, to date, has mainly targeted nucleophilic functional groups, such as...

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Detalles Bibliográficos
Autores principales: Matthews, Megan L, He, Lin, Horning, Benjamin D, Olson, Erika J, Correia, Bruno E, Yates, John R, Dawson, Philip E, Cravatt, Benjamin F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325178/
https://www.ncbi.nlm.nih.gov/pubmed/28221344
http://dx.doi.org/10.1038/nchem.2645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325178/
https://www.ncbi.nlm.nih.gov/pubmed/28221344
http://dx.doi.org/10.1038/nchem.2645

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