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High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men

We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual hea...

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Autores principales: Lee, Jieun, Yoon, Kijung, Ryu, Seungho, Chang, Yoosoo, Kim, Hyoung-Ryoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325306/
https://www.ncbi.nlm.nih.gov/pubmed/28234943
http://dx.doi.org/10.1371/journal.pone.0172666
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author Lee, Jieun
Yoon, Kijung
Ryu, Seungho
Chang, Yoosoo
Kim, Hyoung-Ryoul
author_facet Lee, Jieun
Yoon, Kijung
Ryu, Seungho
Chang, Yoosoo
Kim, Hyoung-Ryoul
author_sort Lee, Jieun
collection PubMed
description We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (p< 0.001). As the hs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development.
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spelling pubmed-53253062017-03-09 High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men Lee, Jieun Yoon, Kijung Ryu, Seungho Chang, Yoosoo Kim, Hyoung-Ryoul PLoS One Research Article We performed a follow-up study to address whether high sensitivity C-reactive protein (hs-CRP) levels within the normal range can predict the development of non-alcoholic fatty liver disease (NAFLD) in healthy male subjects. Among15347 male workers between 30 and 59 years old who received annual health check-ups in 2002, a NAFLD-free cohort of 4,138 was followed through December 2009. Alcohol consumption was assessed with a questionnaire. At each visit, abdominal ultrasonography was performed to identify fatty liver disease. The COX proportional hazard model was used to evaluate the relationship between hs-CRP and incident NAFLD. During the follow-up period, 28.8% (1191 of 4138) of participants developed NAFLD. The hazard ratios of NAFLD were increased by hs-CRP categories within the normal range in the non-adjusted model and age-adjusted model. After adjusting for age, exercise, smoking, BMI, systolic BP, triglyceride, and fasting glucose, these incidences were only increased between the lowest and the highest hs-CRP categories. The risk for NAFLD increased as the hs-CRP level increased (p< 0.001). As the hs-CRP level increased within the healthy cohort, the risk of developing NAFLD increased. This trend remained true even if the hs-CRP level remained within the normal range. hs-CRP can be used as a predictor of NAFLD, as well as other obesity-associated diseases. Therefore, individuals with higher hs-CRP levels (even within the normal range) may require appropriate follow-up and management to prevent NAFLD development. Public Library of Science 2017-02-24 /pmc/articles/PMC5325306/ /pubmed/28234943 http://dx.doi.org/10.1371/journal.pone.0172666 Text en © 2017 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Jieun
Yoon, Kijung
Ryu, Seungho
Chang, Yoosoo
Kim, Hyoung-Ryoul
High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
title High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
title_full High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
title_fullStr High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
title_full_unstemmed High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
title_short High-normal levels of hs-CRP predict the development of non-alcoholic fatty liver in healthy men
title_sort high-normal levels of hs-crp predict the development of non-alcoholic fatty liver in healthy men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325306/
https://www.ncbi.nlm.nih.gov/pubmed/28234943
http://dx.doi.org/10.1371/journal.pone.0172666
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