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A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1

The present study revealed the anti-aging properties of antcin M (ANM) and elucidated the molecular mechanism underlying the effects. We found that exposure of human normal dermal fibroblasts (HNDFs) to high-glucose (HG, 30 mM) for 3 days, accelerated G(0)/G(1) phase arrest and senescence. Indeed, c...

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Detalles Bibliográficos
Autores principales:	Senthil, Kumar K.J., Gokila, Vani M., Mau, Jeng-Leun, Lin, Chin-Chung, Chu, Fang-Hua, Wei, Chia-Cheng, Liao, Vivian Hsiu-Chuan, Wang, Sheng-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325331/ https://www.ncbi.nlm.nih.gov/pubmed/27542238 http://dx.doi.org/10.18632/oncotarget.11229

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