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MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

Fumagillin and its derivatives are therapeutically useful because they can decrease cancer progression. The specific molecular target of fumagillin is methionine aminopeptidase 2 (MetAP2), one of the two MetAPs present in the cytosol. MetAPs catalyze N-terminal methionine excision (NME), an essentia...

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Detalles Bibliográficos
Autores principales:	Frottin, Frédéric, Bienvenut, Willy V., Bignon, Jérôme, Jacquet, Eric, Jacome, Alvaro Sebastian Vaca, Van Dorsselaer, Alain, Cianferani, Sarah, Carapito, Christine, Meinnel, Thierry, Giglione, Carmela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325365/ https://www.ncbi.nlm.nih.gov/pubmed/27542228 http://dx.doi.org/10.18632/oncotarget.11216

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