Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

Current therapy of osteosarcoma (OS), the most common primary bone malignancy, is based on a combination of surgery and chemotherapy. Multidrug resistance mediated by P-glycoprotein (P-gp) overexpression has been previously associated with treatment failure and progression of OS, although other mech...

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Detalles Bibliográficos
Autores principales: Avnet, Sofia, Lemma, Silvia, Cortini, Margherita, Pellegrini, Paola, Perut, Francesca, Zini, Nicoletta, Kusuzaki, Katsuyuki, Chano, Tokuhiro, Grisendi, Giulia, Dominici, Massimo, De Milito, Angelo, Baldini, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325373/
https://www.ncbi.nlm.nih.gov/pubmed/27566564
http://dx.doi.org/10.18632/oncotarget.11503

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