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Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22

Long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNAs, is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, the aberrant up-...

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Autores principales: Luan, Wenkang, Li, Lubo, Shi, Yan, Bu, Xuefeng, Xia, Yun, Wang, Jinlong, Djangmah, Henry Siaw, Liu, Xiaohui, You, Yongping, Xu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325412/
https://www.ncbi.nlm.nih.gov/pubmed/27564100
http://dx.doi.org/10.18632/oncotarget.11564
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author Luan, Wenkang
Li, Lubo
Shi, Yan
Bu, Xuefeng
Xia, Yun
Wang, Jinlong
Djangmah, Henry Siaw
Liu, Xiaohui
You, Yongping
Xu, Bin
author_facet Luan, Wenkang
Li, Lubo
Shi, Yan
Bu, Xuefeng
Xia, Yun
Wang, Jinlong
Djangmah, Henry Siaw
Liu, Xiaohui
You, Yongping
Xu, Bin
author_sort Luan, Wenkang
collection PubMed
description Long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNAs, is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, the aberrant up-regulation of MALAT1 was detected in melanoma. We determined that MALAT1 promotes melanoma cells proliferation, invasion and migration by sponging miR-22. MiR-22 was decreased and acted as a tumor suppressor in melanoma, and MMP14 and Snail were the functional targets of miR-22. Furthermore, MALAT1 could modulate MMP14 and Snail by operating as a competing endogenous RNA (ceRNA) for miR-22. The effects of MALAT1 in malignant melanoma is verified using a xenograft model. This finding elucidates a new mechanism for MALAT1 in melanoma development and provides a potential target for melanoma therapeutic intervention.
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spelling pubmed-53254122017-03-23 Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22 Luan, Wenkang Li, Lubo Shi, Yan Bu, Xuefeng Xia, Yun Wang, Jinlong Djangmah, Henry Siaw Liu, Xiaohui You, Yongping Xu, Bin Oncotarget Research Paper Long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNAs, is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, the aberrant up-regulation of MALAT1 was detected in melanoma. We determined that MALAT1 promotes melanoma cells proliferation, invasion and migration by sponging miR-22. MiR-22 was decreased and acted as a tumor suppressor in melanoma, and MMP14 and Snail were the functional targets of miR-22. Furthermore, MALAT1 could modulate MMP14 and Snail by operating as a competing endogenous RNA (ceRNA) for miR-22. The effects of MALAT1 in malignant melanoma is verified using a xenograft model. This finding elucidates a new mechanism for MALAT1 in melanoma development and provides a potential target for melanoma therapeutic intervention. Impact Journals LLC 2016-08-24 /pmc/articles/PMC5325412/ /pubmed/27564100 http://dx.doi.org/10.18632/oncotarget.11564 Text en Copyright: © 2016 Luan et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Luan, Wenkang
Li, Lubo
Shi, Yan
Bu, Xuefeng
Xia, Yun
Wang, Jinlong
Djangmah, Henry Siaw
Liu, Xiaohui
You, Yongping
Xu, Bin
Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22
title Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22
title_full Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22
title_fullStr Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22
title_full_unstemmed Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22
title_short Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22
title_sort long non-coding rna malat1 acts as a competing endogenous rna to promote malignant melanoma growth and metastasis by sponging mir-22
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325412/
https://www.ncbi.nlm.nih.gov/pubmed/27564100
http://dx.doi.org/10.18632/oncotarget.11564
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