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DMBA induced mouse mammary tumors display high incidence of activating Pik3ca(H1047) and loss of function Pten mutations

Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenza...

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Detalles Bibliográficos
Autores principales:	Abba, Martín C., Zhong, Yi, Lee, Jaeho, Kil, Hyunsuk, Lu, Yue, Takata, Yoko, Simper, Melissa S., Gaddis, Sally, Shen, Jianjun, Aldaz, C. Marcelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325442/ https://www.ncbi.nlm.nih.gov/pubmed/27588403 http://dx.doi.org/10.18632/oncotarget.11733

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