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Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency

Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs) are thought to inhibit Wnt signaling pathway through binding to lipoprotein receptor-related protein (LRP) 5/6. In this study, based on the 3-dimensional (3D) structure of...

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Detalles Bibliográficos
Autores principales:	Poorebrahim, Mansour, Sadeghi, Solmaz, Rahimi, Hamzeh, Karimipoor, Morteza, Azadmanesh, Kayhan, Mazlomi, Mohammad Ali, Teimoori-Toolabi, Ladan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325476/ https://www.ncbi.nlm.nih.gov/pubmed/28234935 http://dx.doi.org/10.1371/journal.pone.0172217

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