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The single nucleotide variant rs12722489 determines differential estrogen receptor binding and enhancer properties of an IL2RA intronic region

We studied functional effect of rs12722489 single nucleotide polymorphism located in the first intron of human IL2RA gene on transcriptional regulation. This polymorphism is associated with multiple autoimmune conditions (rheumatoid arthritis, multiple sclerosis, Crohn's disease, and ulcerative...

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Detalles Bibliográficos
Autores principales:	Afanasyeva, Marina A., Putlyaeva, Lidia V., Demin, Denis E., Kulakovskiy, Ivan V., Vorontsov, Ilya E., Fridman, Marina V., Makeev, Vsevolod J., Kuprash, Dmitry V., Schwartz, Anton M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325477/ https://www.ncbi.nlm.nih.gov/pubmed/28234966 http://dx.doi.org/10.1371/journal.pone.0172681

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