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CD8(+) T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan para...

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Detalles Bibliográficos
Autores principales:	Novais, Fernanda O., Carvalho, Augusto M., Clark, Megan L., Carvalho, Lucas P., Beiting, Daniel P., Brodsky, Igor E., Carvalho, Edgar M., Scott, Phillip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325592/ https://www.ncbi.nlm.nih.gov/pubmed/28192528 http://dx.doi.org/10.1371/journal.ppat.1006196

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