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Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015
BACKGROUND: Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDIN...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325611/ https://www.ncbi.nlm.nih.gov/pubmed/28182662 http://dx.doi.org/10.1371/journal.pntd.0005228 |
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author | Chadsuthi, Sudarat Bicout, Dominique J. Wiratsudakul, Anuwat Suwancharoen, Duangjai Petkanchanapong, Wimol Modchang, Charin Triampo, Wannapong Ratanakorn, Parntep Chalvet-Monfray, Karine |
author_facet | Chadsuthi, Sudarat Bicout, Dominique J. Wiratsudakul, Anuwat Suwancharoen, Duangjai Petkanchanapong, Wimol Modchang, Charin Triampo, Wannapong Ratanakorn, Parntep Chalvet-Monfray, Karine |
author_sort | Chadsuthi, Sudarat |
collection | PubMed |
description | BACKGROUND: Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDINGS: Data on leptospirosis infection in humans and livestock (Buffaloes, Cattle, and Pigs) species during 2010 to 2015 were analyzed. Serum samples were examined using Microscopic Agglutination Test (MAT) to identify antibodies against Leptospira serovars using a cut-off titer ≥ 1:100. The seroprevalence was 23.7% in humans, 24.8% in buffaloes, 28.1% in cattle, and 11.3% in pigs. Region specific prevalence among humans and livestock was found in a wide range. The most predominant serovars were Shermani, followed by Bratislava, Panama, and Sejroe in human, Shermani, Ranarum, and Tarassovi in buffaloes, and Shermani and Ranarum in cattle and pigs. Equally highest MAT titers against multiple serovars per one sample were found mainly in buffaloes and cattle showing equally titers against Ranarum and Shermani. The correlations of distribution of serovars across Thailand’s regions were found to be similar in pattern for cattle but not for buffaloes. In humans, the serovar distribution in the south differed from other regions. By logistic regression, the results indicated that livestock is more susceptible to infection by serovar Shermani when compared to humans. CONCLUSIONS/SIGNIFICANCE: This study gives a detailed picture of the predominance of Leptospira serovars in relation to region, humans and typical livestock. The broad spatial distribution of seroprevalence was analyzed across and within species as well as regions in Thailand. Our finding may guide public health policy makers to implement appropriate control measures and help to reduce the impact of leptospirosis in Thailand. |
format | Online Article Text |
id | pubmed-5325611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53256112017-03-10 Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 Chadsuthi, Sudarat Bicout, Dominique J. Wiratsudakul, Anuwat Suwancharoen, Duangjai Petkanchanapong, Wimol Modchang, Charin Triampo, Wannapong Ratanakorn, Parntep Chalvet-Monfray, Karine PLoS Negl Trop Dis Research Article BACKGROUND: Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDINGS: Data on leptospirosis infection in humans and livestock (Buffaloes, Cattle, and Pigs) species during 2010 to 2015 were analyzed. Serum samples were examined using Microscopic Agglutination Test (MAT) to identify antibodies against Leptospira serovars using a cut-off titer ≥ 1:100. The seroprevalence was 23.7% in humans, 24.8% in buffaloes, 28.1% in cattle, and 11.3% in pigs. Region specific prevalence among humans and livestock was found in a wide range. The most predominant serovars were Shermani, followed by Bratislava, Panama, and Sejroe in human, Shermani, Ranarum, and Tarassovi in buffaloes, and Shermani and Ranarum in cattle and pigs. Equally highest MAT titers against multiple serovars per one sample were found mainly in buffaloes and cattle showing equally titers against Ranarum and Shermani. The correlations of distribution of serovars across Thailand’s regions were found to be similar in pattern for cattle but not for buffaloes. In humans, the serovar distribution in the south differed from other regions. By logistic regression, the results indicated that livestock is more susceptible to infection by serovar Shermani when compared to humans. CONCLUSIONS/SIGNIFICANCE: This study gives a detailed picture of the predominance of Leptospira serovars in relation to region, humans and typical livestock. The broad spatial distribution of seroprevalence was analyzed across and within species as well as regions in Thailand. Our finding may guide public health policy makers to implement appropriate control measures and help to reduce the impact of leptospirosis in Thailand. Public Library of Science 2017-02-09 /pmc/articles/PMC5325611/ /pubmed/28182662 http://dx.doi.org/10.1371/journal.pntd.0005228 Text en © 2017 Chadsuthi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Chadsuthi, Sudarat Bicout, Dominique J. Wiratsudakul, Anuwat Suwancharoen, Duangjai Petkanchanapong, Wimol Modchang, Charin Triampo, Wannapong Ratanakorn, Parntep Chalvet-Monfray, Karine Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 |
title | Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 |
title_full | Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 |
title_fullStr | Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 |
title_full_unstemmed | Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 |
title_short | Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015 |
title_sort | investigation on predominant leptospira serovars and its distribution in humans and livestock in thailand, 2010-2015 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325611/ https://www.ncbi.nlm.nih.gov/pubmed/28182662 http://dx.doi.org/10.1371/journal.pntd.0005228 |
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