Phosphorylation of β-arrestin2 at Thr(383) by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs

In addition to their role in desensitization and internalization of G protein-coupled receptors (GPCRs), β-arrestins are essential scaffolds linking GPCRs to Erk1/2 signaling. However, their role in GPCR-operated Erk1/2 activation differs between GPCRs and the underlying mechanism remains poorly cha...

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Detalles Bibliográficos
Autores principales: Cassier, Elisabeth, Gallay, Nathalie, Bourquard, Thomas, Claeysen, Sylvie, Bockaert, Joël, Crépieux, Pascale, Poupon, Anne, Reiter, Eric, Marin, Philippe, Vandermoere, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325621/
https://www.ncbi.nlm.nih.gov/pubmed/28169830
http://dx.doi.org/10.7554/eLife.23777

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