Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis

Alcohol is a widely consumed drug that can lead to addiction and severe brain damage. However, alcohol is also used as self-medication for psychiatric problems, such as depression, frequently resulting in depression-alcoholism comorbidity. Here, we identify the first molecular mechanism for alcohol...

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Detalles Bibliográficos
Autores principales: Müller, Christian P., Kalinichenko, Liubov S., Tiesel, Jens, Witt, Matthias, Stöckl, Thomas, Sprenger, Eva, Fuchser, Jens, Beckmann, Janine, Praetner, Marc, Huber, Sabine E., Amato, Davide, Mühle, Christiane, Büttner, Christian, Ekici, Arif B., Smaga, Irena, Pomierny-Chamiolo, Lucyna, Pomierny, Bartosz, Filip, Malgorzata, Eulenburg, Volker, Gulbins, Erich, Lourdusamy, Anbarasu, Reichel, Martin, Kornhuber, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325869/
https://www.ncbi.nlm.nih.gov/pubmed/28000031
http://dx.doi.org/10.1007/s00401-016-1658-6

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