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Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports
BACKGROUND: Tumor biopsy for histological diagnosis is required preoperatively and before initiating chemotherapy or radiation therapy for patients with pancreatic cancer (Cancer of the Pancreas: Clinical Practice Guidelines, European Society for Medical Oncology). Endoscopic ultrasound fine-needle...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326629/ https://www.ncbi.nlm.nih.gov/pubmed/28238191 http://dx.doi.org/10.1186/s40792-017-0314-2 |
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author | Toshiyama, Reishi Noda, Takehiro Eguchi, Hidetoshi Iwagami, Yoshifumi Yamada, Daisaku Asaoka, Tadafumi Wada, Hiroshi Kawamoto, Koichi Gotoh, Kunihito Takeda, Yutaka Tanemura, Masahiro Morii, Eiichi Umeshita, Koji Mori, Masaki Doki, Yuichiro |
author_facet | Toshiyama, Reishi Noda, Takehiro Eguchi, Hidetoshi Iwagami, Yoshifumi Yamada, Daisaku Asaoka, Tadafumi Wada, Hiroshi Kawamoto, Koichi Gotoh, Kunihito Takeda, Yutaka Tanemura, Masahiro Morii, Eiichi Umeshita, Koji Mori, Masaki Doki, Yuichiro |
author_sort | Toshiyama, Reishi |
collection | PubMed |
description | BACKGROUND: Tumor biopsy for histological diagnosis is required preoperatively and before initiating chemotherapy or radiation therapy for patients with pancreatic cancer (Cancer of the Pancreas: Clinical Practice Guidelines, European Society for Medical Oncology). Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is widely applied to obtain tissue samples for histological examination. However, in some cases, EUS-FNA cannot be performed safely or tissue samples are insufficient to establish a definitive diagnosis. We present two cases of pancreatic cancer diagnosed by open surgical biopsy after EUS-FNA failed to yield a diagnosis. CASE PRESENTATION: Case 1 was a 50-year-old man. Computed tomography showed a hypovascular lesion in the uncus of the pancreas. Although EUS-FNA was conducted twice, we could not collect enough quantity of tissue samples to establish a definitive diagnosis. Open surgical biopsy revealed adenocarcinoma, and the patient underwent preoperative chemoradiation therapy followed by curative operation. Case 2 was a 68-year-old man. Computed tomography showed a hypovascular tumor in the uncus of the pancreas. EUS revealed a 14-mm hypoechoic lesion, but we could not perform EUS-FNA because the superior mesenteric vein was located in the puncture line. Open surgical biopsy revealed adenocarcinoma, and the patient underwent preoperative chemoradiation therapy followed by pancreaticoduodenectomy. CONCLUSIONS: EUS-FNA is the first choice in the diagnostic modalities of pancreatic neoplasm, but open surgical biopsy is an effective diagnostic method if EUS-FNA is unsuccessful. |
format | Online Article Text |
id | pubmed-5326629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-53266292017-03-10 Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports Toshiyama, Reishi Noda, Takehiro Eguchi, Hidetoshi Iwagami, Yoshifumi Yamada, Daisaku Asaoka, Tadafumi Wada, Hiroshi Kawamoto, Koichi Gotoh, Kunihito Takeda, Yutaka Tanemura, Masahiro Morii, Eiichi Umeshita, Koji Mori, Masaki Doki, Yuichiro Surg Case Rep Case Report BACKGROUND: Tumor biopsy for histological diagnosis is required preoperatively and before initiating chemotherapy or radiation therapy for patients with pancreatic cancer (Cancer of the Pancreas: Clinical Practice Guidelines, European Society for Medical Oncology). Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is widely applied to obtain tissue samples for histological examination. However, in some cases, EUS-FNA cannot be performed safely or tissue samples are insufficient to establish a definitive diagnosis. We present two cases of pancreatic cancer diagnosed by open surgical biopsy after EUS-FNA failed to yield a diagnosis. CASE PRESENTATION: Case 1 was a 50-year-old man. Computed tomography showed a hypovascular lesion in the uncus of the pancreas. Although EUS-FNA was conducted twice, we could not collect enough quantity of tissue samples to establish a definitive diagnosis. Open surgical biopsy revealed adenocarcinoma, and the patient underwent preoperative chemoradiation therapy followed by curative operation. Case 2 was a 68-year-old man. Computed tomography showed a hypovascular tumor in the uncus of the pancreas. EUS revealed a 14-mm hypoechoic lesion, but we could not perform EUS-FNA because the superior mesenteric vein was located in the puncture line. Open surgical biopsy revealed adenocarcinoma, and the patient underwent preoperative chemoradiation therapy followed by pancreaticoduodenectomy. CONCLUSIONS: EUS-FNA is the first choice in the diagnostic modalities of pancreatic neoplasm, but open surgical biopsy is an effective diagnostic method if EUS-FNA is unsuccessful. Springer Berlin Heidelberg 2017-02-25 /pmc/articles/PMC5326629/ /pubmed/28238191 http://dx.doi.org/10.1186/s40792-017-0314-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Toshiyama, Reishi Noda, Takehiro Eguchi, Hidetoshi Iwagami, Yoshifumi Yamada, Daisaku Asaoka, Tadafumi Wada, Hiroshi Kawamoto, Koichi Gotoh, Kunihito Takeda, Yutaka Tanemura, Masahiro Morii, Eiichi Umeshita, Koji Mori, Masaki Doki, Yuichiro Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
title | Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
title_full | Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
title_fullStr | Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
title_full_unstemmed | Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
title_short | Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
title_sort | two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326629/ https://www.ncbi.nlm.nih.gov/pubmed/28238191 http://dx.doi.org/10.1186/s40792-017-0314-2 |
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