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MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?

This paper aims to present an overview of MICA and natural killer group 2 member D (NKG2D) genetic and functional interactions and their impact on kidney transplant outcome. Organ transplantation has gone from what can accurately be called a “clinical experiment” to a routine and reliable practice,...

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Autores principales: Risti, Matilde, Bicalho, Maria da Graça
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326783/
https://www.ncbi.nlm.nih.gov/pubmed/28289413
http://dx.doi.org/10.3389/fimmu.2017.00179
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author Risti, Matilde
Bicalho, Maria da Graça
author_facet Risti, Matilde
Bicalho, Maria da Graça
author_sort Risti, Matilde
collection PubMed
description This paper aims to present an overview of MICA and natural killer group 2 member D (NKG2D) genetic and functional interactions and their impact on kidney transplant outcome. Organ transplantation has gone from what can accurately be called a “clinical experiment” to a routine and reliable practice, which has proven to be clinically relevant, life-saving and cost-effective when compared with non-transplantation management strategies of both chronic and acute end-stage organ failures. The kidney is the most frequently transplanted organ in the world (transplant-observatory). The two treatment options for end-stage renal disease (ESRD) are dialysis and/or transplantation. Compared with dialysis, transplantation is associated with significant improvements in quality of life and overall longevity. A strong relationship exists between allograft loss and human leukocyte antigens (HLA) antibodies (Abs). HLA Abs are not the only factor involved in graft loss, as multiple studies have shown that non-HLA antigens are also involved, even when a patient has a good HLA matche and receives standard immunosuppressive therapy. A deeper understanding of other biomarkers is therefore important, as it is likely to lead to better monitoring (and consequent success) of organ transplants. The objective is to fill the void left by extensive reviews that do not often dive this deep into the importance of MICA and NKG2D in allograft acceptance and their partnership in the immune response. There are few papers that explore the relationship between these two protagonists when it comes to kidney transplantation. This is especially true for the role of NKG2D in kidney transplantation. These reasons give a special importance to this review, which aims to be a helpful tool in the hands of researchers in this field.
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spelling pubmed-53267832017-03-13 MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome? Risti, Matilde Bicalho, Maria da Graça Front Immunol Immunology This paper aims to present an overview of MICA and natural killer group 2 member D (NKG2D) genetic and functional interactions and their impact on kidney transplant outcome. Organ transplantation has gone from what can accurately be called a “clinical experiment” to a routine and reliable practice, which has proven to be clinically relevant, life-saving and cost-effective when compared with non-transplantation management strategies of both chronic and acute end-stage organ failures. The kidney is the most frequently transplanted organ in the world (transplant-observatory). The two treatment options for end-stage renal disease (ESRD) are dialysis and/or transplantation. Compared with dialysis, transplantation is associated with significant improvements in quality of life and overall longevity. A strong relationship exists between allograft loss and human leukocyte antigens (HLA) antibodies (Abs). HLA Abs are not the only factor involved in graft loss, as multiple studies have shown that non-HLA antigens are also involved, even when a patient has a good HLA matche and receives standard immunosuppressive therapy. A deeper understanding of other biomarkers is therefore important, as it is likely to lead to better monitoring (and consequent success) of organ transplants. The objective is to fill the void left by extensive reviews that do not often dive this deep into the importance of MICA and NKG2D in allograft acceptance and their partnership in the immune response. There are few papers that explore the relationship between these two protagonists when it comes to kidney transplantation. This is especially true for the role of NKG2D in kidney transplantation. These reasons give a special importance to this review, which aims to be a helpful tool in the hands of researchers in this field. Frontiers Media S.A. 2017-02-27 /pmc/articles/PMC5326783/ /pubmed/28289413 http://dx.doi.org/10.3389/fimmu.2017.00179 Text en Copyright © 2017 Risti and Bicalho. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Risti, Matilde
Bicalho, Maria da Graça
MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?
title MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?
title_full MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?
title_fullStr MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?
title_full_unstemmed MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?
title_short MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?
title_sort mica and nkg2d: is there an impact on kidney transplant outcome?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326783/
https://www.ncbi.nlm.nih.gov/pubmed/28289413
http://dx.doi.org/10.3389/fimmu.2017.00179
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