The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cSCC) contributes to one of most common types of skin cancer. Epidermal growth factor receptor (EGFR) activation has been investigated to be associated with the development of cSCC. Lapatinib is an inhibitor targeting HER2/neu and EGFR pathway. We found that lapati...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Ming, Shang, Yuan-Yuan, Zhou, Zhi-Wei, Yang, Yin-Xue, Wu, Yin-Sheng, Guan, Li-Feng, Wang, Xin-Yu, Zhou, Shu-Feng, Wei, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327371/
https://www.ncbi.nlm.nih.gov/pubmed/28243326
http://dx.doi.org/10.7150/jca.16850
_version_ 1782510714781433856
author Yao, Ming
Shang, Yuan-Yuan
Zhou, Zhi-Wei
Yang, Yin-Xue
Wu, Yin-Sheng
Guan, Li-Feng
Wang, Xin-Yu
Zhou, Shu-Feng
Wei, Xi
author_facet Yao, Ming
Shang, Yuan-Yuan
Zhou, Zhi-Wei
Yang, Yin-Xue
Wu, Yin-Sheng
Guan, Li-Feng
Wang, Xin-Yu
Zhou, Shu-Feng
Wei, Xi
author_sort Yao, Ming
collection PubMed
description Cutaneous squamous cell carcinoma (cSCC) contributes to one of most common types of skin cancer. Epidermal growth factor receptor (EGFR) activation has been investigated to be associated with the development of cSCC. Lapatinib is an inhibitor targeting HER2/neu and EGFR pathway. We found that lapatinib can inhibit proliferation by enhancing apoptosis of human cSCC cell lines. The cSCC cell cycle distribution could be arrested in G2/M phase after lapatinib treatment. In the in vitro experiment, we found that lapatinib interrupted PI3K/AKT/mTOR signaling pathway in human cSCC cells. Furthermore, lapatinib could suppress epithelial to mesenchymal transition (EMT) via Wnt/ErK/PI3K-AKT signaling pathway to represent a promising anticancer drug for cSCC treatment.
format Online
Article
Text
id pubmed-5327371
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-53273712017-02-27 The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma Yao, Ming Shang, Yuan-Yuan Zhou, Zhi-Wei Yang, Yin-Xue Wu, Yin-Sheng Guan, Li-Feng Wang, Xin-Yu Zhou, Shu-Feng Wei, Xi J Cancer Research Paper Cutaneous squamous cell carcinoma (cSCC) contributes to one of most common types of skin cancer. Epidermal growth factor receptor (EGFR) activation has been investigated to be associated with the development of cSCC. Lapatinib is an inhibitor targeting HER2/neu and EGFR pathway. We found that lapatinib can inhibit proliferation by enhancing apoptosis of human cSCC cell lines. The cSCC cell cycle distribution could be arrested in G2/M phase after lapatinib treatment. In the in vitro experiment, we found that lapatinib interrupted PI3K/AKT/mTOR signaling pathway in human cSCC cells. Furthermore, lapatinib could suppress epithelial to mesenchymal transition (EMT) via Wnt/ErK/PI3K-AKT signaling pathway to represent a promising anticancer drug for cSCC treatment. Ivyspring International Publisher 2017-01-15 /pmc/articles/PMC5327371/ /pubmed/28243326 http://dx.doi.org/10.7150/jca.16850 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Yao, Ming
Shang, Yuan-Yuan
Zhou, Zhi-Wei
Yang, Yin-Xue
Wu, Yin-Sheng
Guan, Li-Feng
Wang, Xin-Yu
Zhou, Shu-Feng
Wei, Xi
The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma
title The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma
title_full The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma
title_fullStr The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma
title_full_unstemmed The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma
title_short The research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via Wnt/ErK/PI3K-AKT signaling pathway in human cutaneous squamous cell carcinoma
title_sort research on lapatinib in autophagy, cell cycle arrest and epithelial to mesenchymal transition via wnt/erk/pi3k-akt signaling pathway in human cutaneous squamous cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327371/
https://www.ncbi.nlm.nih.gov/pubmed/28243326
http://dx.doi.org/10.7150/jca.16850
work_keys_str_mv AT yaoming theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT shangyuanyuan theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT zhouzhiwei theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT yangyinxue theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT wuyinsheng theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT guanlifeng theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT wangxinyu theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT zhoushufeng theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT weixi theresearchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT yaoming researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT shangyuanyuan researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT zhouzhiwei researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT yangyinxue researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT wuyinsheng researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT guanlifeng researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT wangxinyu researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT zhoushufeng researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma
AT weixi researchonlapatinibinautophagycellcyclearrestandepithelialtomesenchymaltransitionviawnterkpi3kaktsignalingpathwayinhumancutaneoussquamouscellcarcinoma

Ejemplares similares