Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site

Aiming at development of potent antitubulin agents targeting colchicine-binding site, a series of novel 5-indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrilederivatives (5a–5v and 7a–7h) were designed based on bioisosterism and hybridization strategies. All these compounds were concisely synthesized...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhai, Xin, Wang, Xiaoqiang, Wang, Jiao, Liu, Jin, Zuo, Daiying, Jiang, Nan, Zeng, Tianfang, Yang, Xiuxiu, Jing, Tongfei, Gong, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327470/
https://www.ncbi.nlm.nih.gov/pubmed/28240326
http://dx.doi.org/10.1038/srep43398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327470/
https://www.ncbi.nlm.nih.gov/pubmed/28240326
http://dx.doi.org/10.1038/srep43398

Ejemplares similares