Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces

Mice with histidine triad nucleotide-binding protein 1 (HINT1) deletion exhibit manic-like symptoms that evolve into depressive-like behavior in response to stressful paradigms. Molecular and electrophysiological studies have indicated that HINT1(−/−) mice exhibit increased PKC, PKA, and GSK3β activ...

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Detalles Bibliográficos
Autores principales: Garzón-Niño, Javier, Rodríguez-Muñoz, María, Cortés-Montero, Elsa, Sánchez-Blázquez, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327482/
https://www.ncbi.nlm.nih.gov/pubmed/28240305
http://dx.doi.org/10.1038/srep43468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327482/
https://www.ncbi.nlm.nih.gov/pubmed/28240305
http://dx.doi.org/10.1038/srep43468

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