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A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature

BACKGROUND: It is not uncommon that a child with a febrile illness of unknown etiology is admitted to the hospital. When the complete blood count reveals a pancytopenia, the diagnostic process can be a real challenge. CASE PRESENTATION: A 13-year girl of Arab-Berber descent presented with abdominal...

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Autores principales: Leen, Irmin, Bruynseels, Peggy, Mukadi, Benoît Kabamba, van Oort, Mark, van den Akker, Machiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327536/
https://www.ncbi.nlm.nih.gov/pubmed/28238286
http://dx.doi.org/10.1186/s13256-017-1225-3
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author Leen, Irmin
Bruynseels, Peggy
Mukadi, Benoît Kabamba
van Oort, Mark
van den Akker, Machiel
author_facet Leen, Irmin
Bruynseels, Peggy
Mukadi, Benoît Kabamba
van Oort, Mark
van den Akker, Machiel
author_sort Leen, Irmin
collection PubMed
description BACKGROUND: It is not uncommon that a child with a febrile illness of unknown etiology is admitted to the hospital. When the complete blood count reveals a pancytopenia, the diagnostic process can be a real challenge. CASE PRESENTATION: A 13-year girl of Arab-Berber descent presented with abdominal pain and fever after a holiday in northwestern Morocco. A complete blood count revealed a pancytopenia and blood smear test results revealed spirochetes. Borrelia hispanica was identified by sequencing the 16S ribosomal ribonucleic acid gene. Our patient was treated with tetracyclines and during this treatment we saw full clinical and hematological recovery. CONCLUSIONS: Borrelia hispanica is a known cause of tick-borne relapsing fever and is transmitted to humans through the bite of soft ticks of the genus Ornithodoros (Alectorobius). Although the link between tick-borne relapsing fever and thrombocytopenia has been documented, there are only a few case reports of tick-borne relapsing fever presenting with pancytopenia. To the best of our knowledge, there is no previous report of Borrelia hispanica presenting with pancytopenia.
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spelling pubmed-53275362017-03-03 A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature Leen, Irmin Bruynseels, Peggy Mukadi, Benoît Kabamba van Oort, Mark van den Akker, Machiel J Med Case Rep Case Report BACKGROUND: It is not uncommon that a child with a febrile illness of unknown etiology is admitted to the hospital. When the complete blood count reveals a pancytopenia, the diagnostic process can be a real challenge. CASE PRESENTATION: A 13-year girl of Arab-Berber descent presented with abdominal pain and fever after a holiday in northwestern Morocco. A complete blood count revealed a pancytopenia and blood smear test results revealed spirochetes. Borrelia hispanica was identified by sequencing the 16S ribosomal ribonucleic acid gene. Our patient was treated with tetracyclines and during this treatment we saw full clinical and hematological recovery. CONCLUSIONS: Borrelia hispanica is a known cause of tick-borne relapsing fever and is transmitted to humans through the bite of soft ticks of the genus Ornithodoros (Alectorobius). Although the link between tick-borne relapsing fever and thrombocytopenia has been documented, there are only a few case reports of tick-borne relapsing fever presenting with pancytopenia. To the best of our knowledge, there is no previous report of Borrelia hispanica presenting with pancytopenia. BioMed Central 2017-02-27 /pmc/articles/PMC5327536/ /pubmed/28238286 http://dx.doi.org/10.1186/s13256-017-1225-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Leen, Irmin
Bruynseels, Peggy
Mukadi, Benoît Kabamba
van Oort, Mark
van den Akker, Machiel
A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature
title A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature
title_full A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature
title_fullStr A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature
title_full_unstemmed A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature
title_short A 13-year old girl with pancytopenia at the presentation of a Borrelia hispanica infection: a case report and review of the literature
title_sort 13-year old girl with pancytopenia at the presentation of a borrelia hispanica infection: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327536/
https://www.ncbi.nlm.nih.gov/pubmed/28238286
http://dx.doi.org/10.1186/s13256-017-1225-3
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