Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis

BACKGROUND: Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in th...

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Detalles Bibliográficos
Autores principales: Hellerud, Bernt C., Orrem, Hilde L., Dybwik, Knut, Pischke, Søren E., Baratt-Due, Andreas, Castellheim, Albert, Fure, Hilde, Bergseth, Grethe, Christiansen, Dorte, Nunn, Miles A., Espevik, Terje, Lau, Corinna, Brandtzæg, Petter, Nielsen, Erik W., Mollnes, Tom E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327570/
https://www.ncbi.nlm.nih.gov/pubmed/28261486
http://dx.doi.org/10.1186/s40560-017-0217-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327570/
https://www.ncbi.nlm.nih.gov/pubmed/28261486
http://dx.doi.org/10.1186/s40560-017-0217-0

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