Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway

An excess of glucocorticoids (GCs) is reported to be one of the most common causes of osteonecrosis of the femoral head (ONFH). In addition, GCs can induce bone cell apoptosis through modulating endoplasmic reticulum (ER) stress. Among the three main signal pathways in ER stress, the PERK (protein k...

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Detalles Bibliográficos
Autores principales: Tao, Shi-Cong, Yuan, Ting, Rui, Bi-Yu, Zhu, Zhen-Zhong, Guo, Shang-Chun, Zhang, Chang-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327646/
https://www.ncbi.nlm.nih.gov/pubmed/28255363
http://dx.doi.org/10.7150/thno.17450

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