Metabolic pattern formation in the tumor microenvironment

Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is l...

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Detalles Bibliográficos
Autores principales: Dai, Ziwei, Locasale, Jason W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327726/
https://www.ncbi.nlm.nih.gov/pubmed/28183842
http://dx.doi.org/10.15252/msb.20167518
Descripción
Sumario:Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction‐diffusion mechanism and is consistent with a Turing‐type model of spatial localization.

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