Metabolic pattern formation in the tumor microenvironment

Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is l...

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Detalles Bibliográficos
Autores principales: Dai, Ziwei, Locasale, Jason W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327726/
https://www.ncbi.nlm.nih.gov/pubmed/28183842
http://dx.doi.org/10.15252/msb.20167518
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author Dai, Ziwei
Locasale, Jason W
author_facet Dai, Ziwei
Locasale, Jason W
author_sort Dai, Ziwei
collection PubMed
description Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction‐diffusion mechanism and is consistent with a Turing‐type model of spatial localization.
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spelling pubmed-53277262017-03-01 Metabolic pattern formation in the tumor microenvironment Dai, Ziwei Locasale, Jason W Mol Syst Biol News & Views Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction‐diffusion mechanism and is consistent with a Turing‐type model of spatial localization. John Wiley and Sons Inc. 2017-02-09 /pmc/articles/PMC5327726/ /pubmed/28183842 http://dx.doi.org/10.15252/msb.20167518 Text en © 2017 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Dai, Ziwei
Locasale, Jason W
Metabolic pattern formation in the tumor microenvironment
title Metabolic pattern formation in the tumor microenvironment
title_full Metabolic pattern formation in the tumor microenvironment
title_fullStr Metabolic pattern formation in the tumor microenvironment
title_full_unstemmed Metabolic pattern formation in the tumor microenvironment
title_short Metabolic pattern formation in the tumor microenvironment
title_sort metabolic pattern formation in the tumor microenvironment
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327726/
https://www.ncbi.nlm.nih.gov/pubmed/28183842
http://dx.doi.org/10.15252/msb.20167518
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AT locasalejasonw metabolicpatternformationinthetumormicroenvironment

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