Cargando…
The clinical impact of serrated colorectal polyps
Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional ade...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327852/ https://www.ncbi.nlm.nih.gov/pubmed/28260946 http://dx.doi.org/10.2147/CLEP.S106257 |
_version_ | 1782510808779980800 |
---|---|
author | O’Connell, Brendon M Crockett, Seth D |
author_facet | O’Connell, Brendon M Crockett, Seth D |
author_sort | O’Connell, Brendon M |
collection | PubMed |
description | Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional adenomas, which tend to be slow growing and polypoid, SPs have unique features that undermine current screening and surveillance practices. For example, sessile serrated polyps (SSPs) are flat, predominately right-sided, and thought to have the potential for rapid growth. Moreover, SSPs are subject to wide variations in endoscopic detection and pathologic interpretation. Unfortunately, little is known about the natural history of SPs, and current guidelines are based largely on expert opinion. In this review, we outline the current taxonomy, epidemiology, and management of SPs with an emphasis on the clinical and public health impact of these lesions. |
format | Online Article Text |
id | pubmed-5327852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53278522017-03-03 The clinical impact of serrated colorectal polyps O’Connell, Brendon M Crockett, Seth D Clin Epidemiol Review Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional adenomas, which tend to be slow growing and polypoid, SPs have unique features that undermine current screening and surveillance practices. For example, sessile serrated polyps (SSPs) are flat, predominately right-sided, and thought to have the potential for rapid growth. Moreover, SSPs are subject to wide variations in endoscopic detection and pathologic interpretation. Unfortunately, little is known about the natural history of SPs, and current guidelines are based largely on expert opinion. In this review, we outline the current taxonomy, epidemiology, and management of SPs with an emphasis on the clinical and public health impact of these lesions. Dove Medical Press 2017-02-22 /pmc/articles/PMC5327852/ /pubmed/28260946 http://dx.doi.org/10.2147/CLEP.S106257 Text en © 2017 O’Connell and Crockett. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review O’Connell, Brendon M Crockett, Seth D The clinical impact of serrated colorectal polyps |
title | The clinical impact of serrated colorectal polyps |
title_full | The clinical impact of serrated colorectal polyps |
title_fullStr | The clinical impact of serrated colorectal polyps |
title_full_unstemmed | The clinical impact of serrated colorectal polyps |
title_short | The clinical impact of serrated colorectal polyps |
title_sort | clinical impact of serrated colorectal polyps |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327852/ https://www.ncbi.nlm.nih.gov/pubmed/28260946 http://dx.doi.org/10.2147/CLEP.S106257 |
work_keys_str_mv | AT oconnellbrendonm theclinicalimpactofserratedcolorectalpolyps AT crockettsethd theclinicalimpactofserratedcolorectalpolyps AT oconnellbrendonm clinicalimpactofserratedcolorectalpolyps AT crockettsethd clinicalimpactofserratedcolorectalpolyps |