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Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm
Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several alle...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328135/ https://www.ncbi.nlm.nih.gov/pubmed/28260912 http://dx.doi.org/10.2147/TCRM.S129133 |
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author | Liu, Ming-Hui Chan, Ming-Jen Hsu, Ching-Wei Weng, Cheng-Hao Yen, Tzung-Hai Huang, Wen-Hung |
author_facet | Liu, Ming-Hui Chan, Ming-Jen Hsu, Ching-Wei Weng, Cheng-Hao Yen, Tzung-Hai Huang, Wen-Hung |
author_sort | Liu, Ming-Hui |
collection | PubMed |
description | Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 μm [PM(10)] and PM with a diameter of <2.5 μm [PM(2.5)]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD). We analyzed the number of days of mean 24-hour PM(10) ≥125 μg/m(3)/12 months (NDPM(10)) or the number of days of mean 24-hour PM(2.5) ≥35 μg/m(3)/12 months (NDPM(2.5)) exceeding the standard level in the past 12 months respectively to determine the association with UP. In a multivariate logistic regression, HD duration, serum ferritin levels, low-density lipoprotein (LDL) levels, and NDPM(2.5) ≥116 days/12 months were positively associated with UP. This cross-sectional study showed that the number of days on which the environmental PM(2.5) exceeds the standard level might be associated with UP in patients on MHD. |
format | Online Article Text |
id | pubmed-5328135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53281352017-03-03 Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm Liu, Ming-Hui Chan, Ming-Jen Hsu, Ching-Wei Weng, Cheng-Hao Yen, Tzung-Hai Huang, Wen-Hung Ther Clin Risk Manag Original Research Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 μm [PM(10)] and PM with a diameter of <2.5 μm [PM(2.5)]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD). We analyzed the number of days of mean 24-hour PM(10) ≥125 μg/m(3)/12 months (NDPM(10)) or the number of days of mean 24-hour PM(2.5) ≥35 μg/m(3)/12 months (NDPM(2.5)) exceeding the standard level in the past 12 months respectively to determine the association with UP. In a multivariate logistic regression, HD duration, serum ferritin levels, low-density lipoprotein (LDL) levels, and NDPM(2.5) ≥116 days/12 months were positively associated with UP. This cross-sectional study showed that the number of days on which the environmental PM(2.5) exceeds the standard level might be associated with UP in patients on MHD. Dove Medical Press 2017-02-23 /pmc/articles/PMC5328135/ /pubmed/28260912 http://dx.doi.org/10.2147/TCRM.S129133 Text en © 2017 Liu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Liu, Ming-Hui Chan, Ming-Jen Hsu, Ching-Wei Weng, Cheng-Hao Yen, Tzung-Hai Huang, Wen-Hung Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
title | Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
title_full | Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
title_fullStr | Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
title_full_unstemmed | Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
title_short | Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
title_sort | association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328135/ https://www.ncbi.nlm.nih.gov/pubmed/28260912 http://dx.doi.org/10.2147/TCRM.S129133 |
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