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Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review

PURPOSE: Nonadherence to hormone therapy in breast cancer survivors is common and associated with increased risk of mortality. Consistent predictors of nonadherence and nonpersistence are yet to be identified, and little research has examined psychosocial factors that may be amenable to change throu...

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Autores principales: Moon, Zoe, Moss-Morris, Rona, Hunter, Myra S, Carlisle, Sophie, Hughes, Lyndsay D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328144/
https://www.ncbi.nlm.nih.gov/pubmed/28260867
http://dx.doi.org/10.2147/PPA.S126651
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author Moon, Zoe
Moss-Morris, Rona
Hunter, Myra S
Carlisle, Sophie
Hughes, Lyndsay D
author_facet Moon, Zoe
Moss-Morris, Rona
Hunter, Myra S
Carlisle, Sophie
Hughes, Lyndsay D
author_sort Moon, Zoe
collection PubMed
description PURPOSE: Nonadherence to hormone therapy in breast cancer survivors is common and associated with increased risk of mortality. Consistent predictors of nonadherence and nonpersistence are yet to be identified, and little research has examined psychosocial factors that may be amenable to change through intervention. This review aimed to identify predictors of nonadherence and nonpersistence to hormone therapy in breast cancer survivors in order to inform development of an intervention to increase adherence rates. METHODS: Studies published up to April 2016 were identified through MEDLINE, Embase, Web of Science, PsycINFO, CINAHL and gray literature. Studies published in English measuring associations between adherence or persistence and any predictor variables were included. Eligible studies were assessed for methodological quality, data were extracted and a narrative synthesis was conducted. RESULTS: Sixty-one eligible articles were identified. Most studies focused on clinical and demographic factors with inconsistent results. Some evidence suggested that receiving specialist care and social support were related to increased persistence, younger age and increased number of hospitalizations were associated with nonadherence, and good patient–physician relationship and self-efficacy for taking medication were associated with better adherence. A small amount of evidence suggested that medication beliefs were associated with adherence, but more high-quality research is needed to confirm this. CONCLUSION: Some psychosocial variables were associated with better adherence and persistence, but the results are currently tentative. Future high-quality research should be carried out to identify psychosocial determinants of nonadherence or nonpersistence that are modifiable through intervention.
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spelling pubmed-53281442017-03-03 Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review Moon, Zoe Moss-Morris, Rona Hunter, Myra S Carlisle, Sophie Hughes, Lyndsay D Patient Prefer Adherence Review PURPOSE: Nonadherence to hormone therapy in breast cancer survivors is common and associated with increased risk of mortality. Consistent predictors of nonadherence and nonpersistence are yet to be identified, and little research has examined psychosocial factors that may be amenable to change through intervention. This review aimed to identify predictors of nonadherence and nonpersistence to hormone therapy in breast cancer survivors in order to inform development of an intervention to increase adherence rates. METHODS: Studies published up to April 2016 were identified through MEDLINE, Embase, Web of Science, PsycINFO, CINAHL and gray literature. Studies published in English measuring associations between adherence or persistence and any predictor variables were included. Eligible studies were assessed for methodological quality, data were extracted and a narrative synthesis was conducted. RESULTS: Sixty-one eligible articles were identified. Most studies focused on clinical and demographic factors with inconsistent results. Some evidence suggested that receiving specialist care and social support were related to increased persistence, younger age and increased number of hospitalizations were associated with nonadherence, and good patient–physician relationship and self-efficacy for taking medication were associated with better adherence. A small amount of evidence suggested that medication beliefs were associated with adherence, but more high-quality research is needed to confirm this. CONCLUSION: Some psychosocial variables were associated with better adherence and persistence, but the results are currently tentative. Future high-quality research should be carried out to identify psychosocial determinants of nonadherence or nonpersistence that are modifiable through intervention. Dove Medical Press 2017-02-23 /pmc/articles/PMC5328144/ /pubmed/28260867 http://dx.doi.org/10.2147/PPA.S126651 Text en © 2017 Moon et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Moon, Zoe
Moss-Morris, Rona
Hunter, Myra S
Carlisle, Sophie
Hughes, Lyndsay D
Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
title Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
title_full Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
title_fullStr Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
title_full_unstemmed Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
title_short Barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
title_sort barriers and facilitators of adjuvant hormone therapy adherence and persistence in women with breast cancer: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328144/
https://www.ncbi.nlm.nih.gov/pubmed/28260867
http://dx.doi.org/10.2147/PPA.S126651
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