GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of glomerulonephritis worldwide, but specific genetic factors involved in its determination are not known. We performed a quantitative GWAS for serum levels of...

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Detalles Bibliográficos
Autores principales: Kiryluk, Krzysztof, Li, Yifu, Moldoveanu, Zina, Suzuki, Hitoshi, Reily, Colin, Hou, Ping, Xie, Jingyuan, Mladkova, Nikol, Prakash, Sindhuri, Fischman, Clara, Shapiro, Samantha, LeDesma, Robert A., Bradbury, Drew, Ionita-Laza, Iuliana, Eitner, Frank, Rauen, Thomas, Maillard, Nicolas, Berthoux, Francois, Floege, Jürgen, Chen, Nan, Zhang, Hong, Scolari, Francesco, Wyatt, Robert J., Julian, Bruce A., Gharavi, Ali G., Novak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328405/
https://www.ncbi.nlm.nih.gov/pubmed/28187132
http://dx.doi.org/10.1371/journal.pgen.1006609

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