pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where...

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Autores principales: Sutherland, Colin J., Lansdell, Paul, Sanders, Mandy, Muwanguzi, Julian, van Schalkwyk, Donelly A., Kaur, Harparkash, Nolder, Debbie, Tucker, Julie, Bennett, Hayley M., Otto, Thomas D., Berriman, Matthew, Patel, Trupti A., Lynn, Roderick, Gkrania-Klotsas, Effrossyni, Chiodini, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328508/
https://www.ncbi.nlm.nih.gov/pubmed/28137810
http://dx.doi.org/10.1128/AAC.02382-16
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author Sutherland, Colin J.
Lansdell, Paul
Sanders, Mandy
Muwanguzi, Julian
van Schalkwyk, Donelly A.
Kaur, Harparkash
Nolder, Debbie
Tucker, Julie
Bennett, Hayley M.
Otto, Thomas D.
Berriman, Matthew
Patel, Trupti A.
Lynn, Roderick
Gkrania-Klotsas, Effrossyni
Chiodini, Peter L.
author_facet Sutherland, Colin J.
Lansdell, Paul
Sanders, Mandy
Muwanguzi, Julian
van Schalkwyk, Donelly A.
Kaur, Harparkash
Nolder, Debbie
Tucker, Julie
Bennett, Hayley M.
Otto, Thomas D.
Berriman, Matthew
Patel, Trupti A.
Lynn, Roderick
Gkrania-Klotsas, Effrossyni
Chiodini, Peter L.
author_sort Sutherland, Colin J.
collection PubMed
description We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.
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spelling pubmed-53285082017-03-09 pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom Sutherland, Colin J. Lansdell, Paul Sanders, Mandy Muwanguzi, Julian van Schalkwyk, Donelly A. Kaur, Harparkash Nolder, Debbie Tucker, Julie Bennett, Hayley M. Otto, Thomas D. Berriman, Matthew Patel, Trupti A. Lynn, Roderick Gkrania-Klotsas, Effrossyni Chiodini, Peter L. Antimicrob Agents Chemother Clinical Therapeutics We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended. American Society for Microbiology 2017-02-23 /pmc/articles/PMC5328508/ /pubmed/28137810 http://dx.doi.org/10.1128/AAC.02382-16 Text en Copyright © 2017 Sutherland et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Therapeutics
Sutherland, Colin J.
Lansdell, Paul
Sanders, Mandy
Muwanguzi, Julian
van Schalkwyk, Donelly A.
Kaur, Harparkash
Nolder, Debbie
Tucker, Julie
Bennett, Hayley M.
Otto, Thomas D.
Berriman, Matthew
Patel, Trupti A.
Lynn, Roderick
Gkrania-Klotsas, Effrossyni
Chiodini, Peter L.
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
title pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
title_full pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
title_fullStr pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
title_full_unstemmed pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
title_short pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
title_sort pfk13-independent treatment failure in four imported cases of plasmodium falciparum malaria treated with artemether-lumefantrine in the united kingdom
topic Clinical Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328508/
https://www.ncbi.nlm.nih.gov/pubmed/28137810
http://dx.doi.org/10.1128/AAC.02382-16
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