In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress

The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susce...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Crystal L., Singh, Shweta S., Alamneh, Yonas, Casella, Leila G., Ernst, Robert K., Lesho, Emil P., Waterman, Paige E., Zurawski, Daniel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328574/
https://www.ncbi.nlm.nih.gov/pubmed/27993849
http://dx.doi.org/10.1128/AAC.00598-16
_version_ 1782510910983634944
author Jones, Crystal L.
Singh, Shweta S.
Alamneh, Yonas
Casella, Leila G.
Ernst, Robert K.
Lesho, Emil P.
Waterman, Paige E.
Zurawski, Daniel V.
author_facet Jones, Crystal L.
Singh, Shweta S.
Alamneh, Yonas
Casella, Leila G.
Ernst, Robert K.
Lesho, Emil P.
Waterman, Paige E.
Zurawski, Daniel V.
author_sort Jones, Crystal L.
collection PubMed
description The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistin-susceptible (CS) strains.
format Online
Article
Text
id pubmed-5328574
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-53285742017-03-09 In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress Jones, Crystal L. Singh, Shweta S. Alamneh, Yonas Casella, Leila G. Ernst, Robert K. Lesho, Emil P. Waterman, Paige E. Zurawski, Daniel V. Antimicrob Agents Chemother Mechanisms of Resistance The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistin-susceptible (CS) strains. American Society for Microbiology 2017-02-23 /pmc/articles/PMC5328574/ /pubmed/27993849 http://dx.doi.org/10.1128/AAC.00598-16 Text en Copyright © 2017 Jones et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Jones, Crystal L.
Singh, Shweta S.
Alamneh, Yonas
Casella, Leila G.
Ernst, Robert K.
Lesho, Emil P.
Waterman, Paige E.
Zurawski, Daniel V.
In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
title In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
title_full In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
title_fullStr In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
title_full_unstemmed In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
title_short In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress
title_sort in vivo fitness adaptations of colistin-resistant acinetobacter baumannii isolates to oxidative stress
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328574/
https://www.ncbi.nlm.nih.gov/pubmed/27993849
http://dx.doi.org/10.1128/AAC.00598-16
work_keys_str_mv AT jonescrystall invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT singhshwetas invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT alamnehyonas invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT casellaleilag invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT ernstrobertk invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT leshoemilp invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT watermanpaigee invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress
AT zurawskidanielv invivofitnessadaptationsofcolistinresistantacinetobacterbaumanniiisolatestooxidativestress

Ejemplares similares