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A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous recombination (HR) in G1 cells. The RIF1-dependent...

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Detalles Bibliográficos
Autores principales:	Luijsterburg, Martijn S, Typas, Dimitris, Caron, Marie-Christine, Wiegant, Wouter W, van den Heuvel, Diana, Boonen, Rick A, Couturier, Anthony M, Mullenders, Leon H, Masson, Jean-Yves, van Attikum, Haico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328590/ https://www.ncbi.nlm.nih.gov/pubmed/28240985 http://dx.doi.org/10.7554/eLife.20922

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