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My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy

Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and...

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Autores principales: Brahma, Manoja K., Pepin, Mark E., Wende, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328690/
https://www.ncbi.nlm.nih.gov/pubmed/28236380
http://dx.doi.org/10.4093/dmj.2017.41.1.1
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author Brahma, Manoja K.
Pepin, Mark E.
Wende, Adam R.
author_facet Brahma, Manoja K.
Pepin, Mark E.
Wende, Adam R.
author_sort Brahma, Manoja K.
collection PubMed
description Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed "glycemic memory." In response to chronically elevated glucose levels, a number of studies have identified molecular targets of the glucose-mediated protein posttranslational modification by the addition of an O-linked N-acetylglucosamine to impair contractility, calcium sensitivity, and mitochondrial protein function. Additionally, elevated glucose contributes to dysfunction in coupling glycolysis to glucose oxidation, pentose phosphate pathway, and polyol pathway. Therefore, in the "sweetened" environment associated with hyperglycemia, there are a number of pathways contributing to increased susceptibly to "breaking" the heart of diabetics. In this review we will discuss the unique contribution of glucose to heart disease and recent advances in defining mechanisms of action.
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spelling pubmed-53286902017-02-28 My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy Brahma, Manoja K. Pepin, Mark E. Wende, Adam R. Diabetes Metab J Review Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed "glycemic memory." In response to chronically elevated glucose levels, a number of studies have identified molecular targets of the glucose-mediated protein posttranslational modification by the addition of an O-linked N-acetylglucosamine to impair contractility, calcium sensitivity, and mitochondrial protein function. Additionally, elevated glucose contributes to dysfunction in coupling glycolysis to glucose oxidation, pentose phosphate pathway, and polyol pathway. Therefore, in the "sweetened" environment associated with hyperglycemia, there are a number of pathways contributing to increased susceptibly to "breaking" the heart of diabetics. In this review we will discuss the unique contribution of glucose to heart disease and recent advances in defining mechanisms of action. Korean Diabetes Association 2017-02 2016-11-15 /pmc/articles/PMC5328690/ /pubmed/28236380 http://dx.doi.org/10.4093/dmj.2017.41.1.1 Text en Copyright © 2017 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Brahma, Manoja K.
Pepin, Mark E.
Wende, Adam R.
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
title My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
title_full My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
title_fullStr My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
title_full_unstemmed My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
title_short My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
title_sort my sweetheart is broken: role of glucose in diabetic cardiomyopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328690/
https://www.ncbi.nlm.nih.gov/pubmed/28236380
http://dx.doi.org/10.4093/dmj.2017.41.1.1
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