A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia

The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant su...

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Detalles Bibliográficos
Autores principales: Hossain, Aneesha, Rafei, Hind, Jariwala, Amar, El-Shami, Khaled
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328712/
https://www.ncbi.nlm.nih.gov/pubmed/28275540
http://dx.doi.org/10.1016/j.lrr.2017.01.001
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author Hossain, Aneesha
Rafei, Hind
Jariwala, Amar
El-Shami, Khaled
author_facet Hossain, Aneesha
Rafei, Hind
Jariwala, Amar
El-Shami, Khaled
author_sort Hossain, Aneesha
collection PubMed
description The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.
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spelling pubmed-53287122017-03-08 A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia Hossain, Aneesha Rafei, Hind Jariwala, Amar El-Shami, Khaled Leuk Res Rep Article The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy. Elsevier 2017-01-24 /pmc/articles/PMC5328712/ /pubmed/28275540 http://dx.doi.org/10.1016/j.lrr.2017.01.001 Text en © 2017 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hossain, Aneesha
Rafei, Hind
Jariwala, Amar
El-Shami, Khaled
A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_full A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_fullStr A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_full_unstemmed A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_short A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
title_sort rare breed: wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328712/
https://www.ncbi.nlm.nih.gov/pubmed/28275540
http://dx.doi.org/10.1016/j.lrr.2017.01.001
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