A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia

Philadelphia (Ph) chromosome is a cytogenetic hallmark of chronic myeloid leukemia (CML). Most patients with CML harbor either the e13a2 or e14a2 BCR-ABL fusion product, while a small subset of the cases expresses e1a2 or e19a2 transcripts. We report a patient with chronic myelomonocytic leukemia (C...

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Autores principales: Yao, Jinjuan, Douer, Dan, Wang, Lu, Arcila, Maria E., Nafa, Khedoudja, Chiu, April
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328719/
https://www.ncbi.nlm.nih.gov/pubmed/28275539
http://dx.doi.org/10.1016/j.lrr.2017.01.003
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author Yao, Jinjuan
Douer, Dan
Wang, Lu
Arcila, Maria E.
Nafa, Khedoudja
Chiu, April
author_facet Yao, Jinjuan
Douer, Dan
Wang, Lu
Arcila, Maria E.
Nafa, Khedoudja
Chiu, April
author_sort Yao, Jinjuan
collection PubMed
description Philadelphia (Ph) chromosome is a cytogenetic hallmark of chronic myeloid leukemia (CML). Most patients with CML harbor either the e13a2 or e14a2 BCR-ABL fusion product, while a small subset of the cases expresses e1a2 or e19a2 transcripts. We report a patient with chronic myelomonocytic leukemia (CMML), initially Ph chromosome negative at presentation, with rapid disease progression to acute myeloid leukemia (AML) and appearance of Ph chromosome and BCR-ABL e6a2, a very uncommon fusion transcript. The AML was refractory to treatment with subsequent emergence and dominance of a Ph negative leukemic clone. The patient expired shortly after disease progression.
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spelling pubmed-53287192017-03-08 A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia Yao, Jinjuan Douer, Dan Wang, Lu Arcila, Maria E. Nafa, Khedoudja Chiu, April Leuk Res Rep Article Philadelphia (Ph) chromosome is a cytogenetic hallmark of chronic myeloid leukemia (CML). Most patients with CML harbor either the e13a2 or e14a2 BCR-ABL fusion product, while a small subset of the cases expresses e1a2 or e19a2 transcripts. We report a patient with chronic myelomonocytic leukemia (CMML), initially Ph chromosome negative at presentation, with rapid disease progression to acute myeloid leukemia (AML) and appearance of Ph chromosome and BCR-ABL e6a2, a very uncommon fusion transcript. The AML was refractory to treatment with subsequent emergence and dominance of a Ph negative leukemic clone. The patient expired shortly after disease progression. Elsevier 2017-01-31 /pmc/articles/PMC5328719/ /pubmed/28275539 http://dx.doi.org/10.1016/j.lrr.2017.01.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yao, Jinjuan
Douer, Dan
Wang, Lu
Arcila, Maria E.
Nafa, Khedoudja
Chiu, April
A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia
title A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia
title_full A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia
title_fullStr A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia
title_full_unstemmed A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia
title_short A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia
title_sort case of acute myeloid leukemia with e6a2 bcr-abl fusion transcript acquired after progressing from chronic myelomonocytic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328719/
https://www.ncbi.nlm.nih.gov/pubmed/28275539
http://dx.doi.org/10.1016/j.lrr.2017.01.003
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