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Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis
INTRODUCTION: Retinal characteristics are increasingly recognized as biomarkers for neurodegenerative diseases. Retinal thickness measured by optical coherence tomography may reflect the presence of Alzheimer's disease (AD). We performed a meta-analysis on retinal thickness in AD and mild cogni...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328759/ https://www.ncbi.nlm.nih.gov/pubmed/28275698 http://dx.doi.org/10.1016/j.dadm.2016.12.014 |
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author | den Haan, Jurre Verbraak, Frank D. Visser, Pieter Jelle Bouwman, Femke H. |
author_facet | den Haan, Jurre Verbraak, Frank D. Visser, Pieter Jelle Bouwman, Femke H. |
author_sort | den Haan, Jurre |
collection | PubMed |
description | INTRODUCTION: Retinal characteristics are increasingly recognized as biomarkers for neurodegenerative diseases. Retinal thickness measured by optical coherence tomography may reflect the presence of Alzheimer's disease (AD). We performed a meta-analysis on retinal thickness in AD and mild cognitive impairment (MCI) patients and healthy controls (HCs). METHODS: We selected 25 studies with measurements of retinal thickness including 887 AD patients, 216 MCI patients, and 864 HCs that measured retinal thickness. Outcomes were peripapillary retinal nerve fiber layer (RNFL) and macular thickness. The main outcome was the standardized mean differences (SMDs). We used STATA to perform the meta-analysis (StataCorp, Texas; version 14.0). RESULTS: Relative to HCs, AD and MCI patients had lower peripapillary RNFL (SMD 0.98 [CI −1.30, −0.66, P < .0001] and SMD 0.71 [CI −1.24, −0.19, P = .008]). Total macular thickness was decreased in AD patients (SMD 0.88 [CI −1.12, −0.65, P = .000]). DISCUSSION: Retinal thickness is decreased in AD and MCI patients compared to HC. This confirms that neurodegenerative diseases may be reflected by retinal changes. |
format | Online Article Text |
id | pubmed-5328759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53287592017-03-08 Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis den Haan, Jurre Verbraak, Frank D. Visser, Pieter Jelle Bouwman, Femke H. Alzheimers Dement (Amst) Retinal Imaging INTRODUCTION: Retinal characteristics are increasingly recognized as biomarkers for neurodegenerative diseases. Retinal thickness measured by optical coherence tomography may reflect the presence of Alzheimer's disease (AD). We performed a meta-analysis on retinal thickness in AD and mild cognitive impairment (MCI) patients and healthy controls (HCs). METHODS: We selected 25 studies with measurements of retinal thickness including 887 AD patients, 216 MCI patients, and 864 HCs that measured retinal thickness. Outcomes were peripapillary retinal nerve fiber layer (RNFL) and macular thickness. The main outcome was the standardized mean differences (SMDs). We used STATA to perform the meta-analysis (StataCorp, Texas; version 14.0). RESULTS: Relative to HCs, AD and MCI patients had lower peripapillary RNFL (SMD 0.98 [CI −1.30, −0.66, P < .0001] and SMD 0.71 [CI −1.24, −0.19, P = .008]). Total macular thickness was decreased in AD patients (SMD 0.88 [CI −1.12, −0.65, P = .000]). DISCUSSION: Retinal thickness is decreased in AD and MCI patients compared to HC. This confirms that neurodegenerative diseases may be reflected by retinal changes. Elsevier 2017-01-25 /pmc/articles/PMC5328759/ /pubmed/28275698 http://dx.doi.org/10.1016/j.dadm.2016.12.014 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Retinal Imaging den Haan, Jurre Verbraak, Frank D. Visser, Pieter Jelle Bouwman, Femke H. Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis |
title | Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis |
title_full | Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis |
title_fullStr | Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis |
title_full_unstemmed | Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis |
title_short | Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis |
title_sort | retinal thickness in alzheimer's disease: a systematic review and meta-analysis |
topic | Retinal Imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328759/ https://www.ncbi.nlm.nih.gov/pubmed/28275698 http://dx.doi.org/10.1016/j.dadm.2016.12.014 |
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