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The role of microbiota in compensatory growth of protein‐restricted rats

Compensatory growth is a physiological phenomenon found in both humans and animals. However, the underlying mechanisms are unclear. In this study, for the first time, we investigated the role of microbiota in compensatory growth induced by protein restriction using a rat model. Weaned Sprague‐Dawley...

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Autores principales: Zhu, Yizhi, Niu, Qingyan, Shi, Chao, Wang, Jing, Zhu, Weiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328828/
https://www.ncbi.nlm.nih.gov/pubmed/27873488
http://dx.doi.org/10.1111/1751-7915.12451
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author Zhu, Yizhi
Niu, Qingyan
Shi, Chao
Wang, Jing
Zhu, Weiyun
author_facet Zhu, Yizhi
Niu, Qingyan
Shi, Chao
Wang, Jing
Zhu, Weiyun
author_sort Zhu, Yizhi
collection PubMed
description Compensatory growth is a physiological phenomenon found in both humans and animals. However, the underlying mechanisms are unclear. In this study, for the first time, we investigated the role of microbiota in compensatory growth induced by protein restriction using a rat model. Weaned Sprague‐Dawley rats were fed a low protein diet (L group), a normal protein diet (N group) and a low protein diet for 2 weeks followed by a normal protein diet (LN group). The results showed that in contrast with the inhibited growth of rats in the L group, compensatory growth was observed in the LN group. Meanwhile, rats in the LN group had increased concentrations of total short chain fatty acids, particularly butyrate, and an altered bacterial composition with modified abundances of Peptostreptococcaceae, Bifidobacteriaceae, Porphyromonadaceae and Prevotellaceae in the colonic content. Furthermore, gene expression analysis indicated that the rats that experienced compensatory growth had improved barrier function and innate immune function in the colon. Our data revealed the importance of colonic microbiota in achieving compensatory growth.
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spelling pubmed-53288282017-03-03 The role of microbiota in compensatory growth of protein‐restricted rats Zhu, Yizhi Niu, Qingyan Shi, Chao Wang, Jing Zhu, Weiyun Microb Biotechnol Research Articles Compensatory growth is a physiological phenomenon found in both humans and animals. However, the underlying mechanisms are unclear. In this study, for the first time, we investigated the role of microbiota in compensatory growth induced by protein restriction using a rat model. Weaned Sprague‐Dawley rats were fed a low protein diet (L group), a normal protein diet (N group) and a low protein diet for 2 weeks followed by a normal protein diet (LN group). The results showed that in contrast with the inhibited growth of rats in the L group, compensatory growth was observed in the LN group. Meanwhile, rats in the LN group had increased concentrations of total short chain fatty acids, particularly butyrate, and an altered bacterial composition with modified abundances of Peptostreptococcaceae, Bifidobacteriaceae, Porphyromonadaceae and Prevotellaceae in the colonic content. Furthermore, gene expression analysis indicated that the rats that experienced compensatory growth had improved barrier function and innate immune function in the colon. Our data revealed the importance of colonic microbiota in achieving compensatory growth. John Wiley and Sons Inc. 2016-11-22 /pmc/articles/PMC5328828/ /pubmed/27873488 http://dx.doi.org/10.1111/1751-7915.12451 Text en © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhu, Yizhi
Niu, Qingyan
Shi, Chao
Wang, Jing
Zhu, Weiyun
The role of microbiota in compensatory growth of protein‐restricted rats
title The role of microbiota in compensatory growth of protein‐restricted rats
title_full The role of microbiota in compensatory growth of protein‐restricted rats
title_fullStr The role of microbiota in compensatory growth of protein‐restricted rats
title_full_unstemmed The role of microbiota in compensatory growth of protein‐restricted rats
title_short The role of microbiota in compensatory growth of protein‐restricted rats
title_sort role of microbiota in compensatory growth of protein‐restricted rats
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328828/
https://www.ncbi.nlm.nih.gov/pubmed/27873488
http://dx.doi.org/10.1111/1751-7915.12451
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