Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group

Classically, β-lactams need an ionizable group to potentiate antibacterial activity. Sets of cephalosporins and penicillins featuring different substituted hydroxamates in place of the traditional carboxylate group have been synthesized and tested for antibiotic activity. Many of the compounds exhib...

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Autores principales: Majewski, Mark W., Miller, Patricia A., Miller, Marvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329033/
https://www.ncbi.nlm.nih.gov/pubmed/27999444
http://dx.doi.org/10.1038/ja.2016.149
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author Majewski, Mark W.
Miller, Patricia A.
Miller, Marvin J.
author_facet Majewski, Mark W.
Miller, Patricia A.
Miller, Marvin J.
author_sort Majewski, Mark W.
collection PubMed
description Classically, β-lactams need an ionizable group to potentiate antibacterial activity. Sets of cephalosporins and penicillins featuring different substituted hydroxamates in place of the traditional carboxylate group have been synthesized and tested for antibiotic activity. Many of the compounds exhibited anti-bacterial activities with notable MIC values in the range of 6-0.2 μM.
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spelling pubmed-53290332017-06-21 Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group Majewski, Mark W. Miller, Patricia A. Miller, Marvin J. J Antibiot (Tokyo) Article Classically, β-lactams need an ionizable group to potentiate antibacterial activity. Sets of cephalosporins and penicillins featuring different substituted hydroxamates in place of the traditional carboxylate group have been synthesized and tested for antibiotic activity. Many of the compounds exhibited anti-bacterial activities with notable MIC values in the range of 6-0.2 μM. 2016-12-21 2017-03 /pmc/articles/PMC5329033/ /pubmed/27999444 http://dx.doi.org/10.1038/ja.2016.149 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Majewski, Mark W.
Miller, Patricia A.
Miller, Marvin J.
Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group
title Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group
title_full Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group
title_fullStr Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group
title_full_unstemmed Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group
title_short Studies at the Ionizable Position of Cephalosporins and Penicillins: Hydroxamates as Substitutes for the Traditional Carboxylate Group
title_sort studies at the ionizable position of cephalosporins and penicillins: hydroxamates as substitutes for the traditional carboxylate group
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329033/
https://www.ncbi.nlm.nih.gov/pubmed/27999444
http://dx.doi.org/10.1038/ja.2016.149
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