Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. How...

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Autores principales: Garg, Pankaj, Morris, Paul, Fazlanie, Asma Lina, Vijayan, Sethumadhavan, Dancso, Balazs, Dastidar, Amardeep Ghosh, Plein, Sven, Mueller, Christian, Haaf, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Im - Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329082/
https://www.ncbi.nlm.nih.gov/pubmed/28188579
http://dx.doi.org/10.1007/s11739-017-1612-1
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author Garg, Pankaj
Morris, Paul
Fazlanie, Asma Lina
Vijayan, Sethumadhavan
Dancso, Balazs
Dastidar, Amardeep Ghosh
Plein, Sven
Mueller, Christian
Haaf, Philip
author_facet Garg, Pankaj
Morris, Paul
Fazlanie, Asma Lina
Vijayan, Sethumadhavan
Dancso, Balazs
Dastidar, Amardeep Ghosh
Plein, Sven
Mueller, Christian
Haaf, Philip
author_sort Garg, Pankaj
collection PubMed
description The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.
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spelling pubmed-53290822017-03-13 Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin Garg, Pankaj Morris, Paul Fazlanie, Asma Lina Vijayan, Sethumadhavan Dancso, Balazs Dastidar, Amardeep Ghosh Plein, Sven Mueller, Christian Haaf, Philip Intern Emerg Med Im - Review The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS. Springer International Publishing 2017-02-11 2017 /pmc/articles/PMC5329082/ /pubmed/28188579 http://dx.doi.org/10.1007/s11739-017-1612-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Im - Review
Garg, Pankaj
Morris, Paul
Fazlanie, Asma Lina
Vijayan, Sethumadhavan
Dancso, Balazs
Dastidar, Amardeep Ghosh
Plein, Sven
Mueller, Christian
Haaf, Philip
Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
title Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
title_full Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
title_fullStr Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
title_full_unstemmed Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
title_short Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
title_sort cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin
topic Im - Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329082/
https://www.ncbi.nlm.nih.gov/pubmed/28188579
http://dx.doi.org/10.1007/s11739-017-1612-1
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