Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels

Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and b...

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Detalles Bibliográficos
Autores principales: Iwaoka, Emiko, Wang, Shenglan, Matsuyoshi, Nobuyuki, Kogure, Yoko, Aoki, Shunji, Yamamoto, Satoshi, Noguchi, Koichi, Dai, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329085/
https://www.ncbi.nlm.nih.gov/pubmed/26188960
http://dx.doi.org/10.1007/s11418-015-0929-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329085/
https://www.ncbi.nlm.nih.gov/pubmed/26188960
http://dx.doi.org/10.1007/s11418-015-0929-1

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