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Evodiamine suppresses capsaicin-induced thermal hyperalgesia through activation and subsequent desensitization of the transient receptor potential V1 channels
Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and b...
Autores principales: | Iwaoka, Emiko, Wang, Shenglan, Matsuyoshi, Nobuyuki, Kogure, Yoko, Aoki, Shunji, Yamamoto, Satoshi, Noguchi, Koichi, Dai, Yi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329085/ https://www.ncbi.nlm.nih.gov/pubmed/26188960 http://dx.doi.org/10.1007/s11418-015-0929-1 |
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