Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the de...

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Autores principales: Sueth-Santiago, Vitor, Decote-Ricardo, Debora, Morrot, Alexandre, Freire-de-Lima, Celio Geraldo, Lima, Marco Edilson Freire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329715/
https://www.ncbi.nlm.nih.gov/pubmed/28289519
http://dx.doi.org/10.4331/wjbc.v8.i1.57
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author Sueth-Santiago, Vitor
Decote-Ricardo, Debora
Morrot, Alexandre
Freire-de-Lima, Celio Geraldo
Lima, Marco Edilson Freire
author_facet Sueth-Santiago, Vitor
Decote-Ricardo, Debora
Morrot, Alexandre
Freire-de-Lima, Celio Geraldo
Lima, Marco Edilson Freire
author_sort Sueth-Santiago, Vitor
collection PubMed
description Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.
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spelling pubmed-53297152017-03-13 Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host Sueth-Santiago, Vitor Decote-Ricardo, Debora Morrot, Alexandre Freire-de-Lima, Celio Geraldo Lima, Marco Edilson Freire World J Biol Chem Review Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host. Baishideng Publishing Group Inc 2017-02-26 2017-02-26 /pmc/articles/PMC5329715/ /pubmed/28289519 http://dx.doi.org/10.4331/wjbc.v8.i1.57 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Sueth-Santiago, Vitor
Decote-Ricardo, Debora
Morrot, Alexandre
Freire-de-Lima, Celio Geraldo
Lima, Marco Edilson Freire
Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
title Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
title_full Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
title_fullStr Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
title_full_unstemmed Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
title_short Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host
title_sort challenges in the chemotherapy of chagas disease: looking for possibilities related to the differences and similarities between the parasite and host
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329715/
https://www.ncbi.nlm.nih.gov/pubmed/28289519
http://dx.doi.org/10.4331/wjbc.v8.i1.57
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