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Tumor-associated macrophages: from basic research to clinical application

The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to b...

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Detalles Bibliográficos
Autores principales: Yang, Li, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329931/
https://www.ncbi.nlm.nih.gov/pubmed/28241846
http://dx.doi.org/10.1186/s13045-017-0430-2
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author Yang, Li
Zhang, Yi
author_facet Yang, Li
Zhang, Yi
author_sort Yang, Li
collection PubMed
description The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages,” contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics.
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spelling pubmed-53299312017-03-03 Tumor-associated macrophages: from basic research to clinical application Yang, Li Zhang, Yi J Hematol Oncol Review The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages,” contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics. BioMed Central 2017-02-28 /pmc/articles/PMC5329931/ /pubmed/28241846 http://dx.doi.org/10.1186/s13045-017-0430-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yang, Li
Zhang, Yi
Tumor-associated macrophages: from basic research to clinical application
title Tumor-associated macrophages: from basic research to clinical application
title_full Tumor-associated macrophages: from basic research to clinical application
title_fullStr Tumor-associated macrophages: from basic research to clinical application
title_full_unstemmed Tumor-associated macrophages: from basic research to clinical application
title_short Tumor-associated macrophages: from basic research to clinical application
title_sort tumor-associated macrophages: from basic research to clinical application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329931/
https://www.ncbi.nlm.nih.gov/pubmed/28241846
http://dx.doi.org/10.1186/s13045-017-0430-2
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