Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

BACKGROUND: The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors have been exclu...

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Detalles Bibliográficos
Autores principales: Pakavathkumar, Prateep, Noël, Anastasia, Lecrux, Clotilde, Tubeleviciute-Aydin, Agne, Hamel, Edith, Ahlfors, Jan-Eric, LeBlanc, Andrea C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329948/
https://www.ncbi.nlm.nih.gov/pubmed/28241839
http://dx.doi.org/10.1186/s13024-017-0166-z

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