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Multiple sclerosis: an example of pathogenic viral interaction?
A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS patients leading to intrathecal B-cell transformati...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330019/ https://www.ncbi.nlm.nih.gov/pubmed/28241767 http://dx.doi.org/10.1186/s12985-017-0719-3 |
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author | Fierz, Walter |
author_facet | Fierz, Walter |
author_sort | Fierz, Walter |
collection | PubMed |
description | A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS patients leading to intrathecal B-cell transformation. Consequent T-cell immune response against the EBV-infected cells is postulated as a pathogenic basis for inflammatory lesion formation in the brain of susceptible individuals. A further link between HHV-6A and EBV involves their induction of expression of the human endogenous retrovirus HERV-K18-encoded superantigen. Such virally induced T-cell responses might secondarily also lead to local autoimmune phenomena. Finally, research recommendations are formulated for substantiating the hypothesis on several levels: epidemiologically, genetically, and viral expression in the brain. |
format | Online Article Text |
id | pubmed-5330019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53300192017-03-03 Multiple sclerosis: an example of pathogenic viral interaction? Fierz, Walter Virol J Review A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS patients leading to intrathecal B-cell transformation. Consequent T-cell immune response against the EBV-infected cells is postulated as a pathogenic basis for inflammatory lesion formation in the brain of susceptible individuals. A further link between HHV-6A and EBV involves their induction of expression of the human endogenous retrovirus HERV-K18-encoded superantigen. Such virally induced T-cell responses might secondarily also lead to local autoimmune phenomena. Finally, research recommendations are formulated for substantiating the hypothesis on several levels: epidemiologically, genetically, and viral expression in the brain. BioMed Central 2017-02-28 /pmc/articles/PMC5330019/ /pubmed/28241767 http://dx.doi.org/10.1186/s12985-017-0719-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Fierz, Walter Multiple sclerosis: an example of pathogenic viral interaction? |
title | Multiple sclerosis: an example of pathogenic viral interaction? |
title_full | Multiple sclerosis: an example of pathogenic viral interaction? |
title_fullStr | Multiple sclerosis: an example of pathogenic viral interaction? |
title_full_unstemmed | Multiple sclerosis: an example of pathogenic viral interaction? |
title_short | Multiple sclerosis: an example of pathogenic viral interaction? |
title_sort | multiple sclerosis: an example of pathogenic viral interaction? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330019/ https://www.ncbi.nlm.nih.gov/pubmed/28241767 http://dx.doi.org/10.1186/s12985-017-0719-3 |
work_keys_str_mv | AT fierzwalter multiplesclerosisanexampleofpathogenicviralinteraction |